This study aimed to compare the effectiveness and safety of fractionated versus bolus administration of different doses of hyperbaric bupivacaine (0.06 and 0.07 mg/cm height) combined with opioids in spinal anesthesia for cesarean section, with detailed evaluation of maternal hemodynamic effects, block characteristics and side effects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
99
* Group F7: received a fractionated administration of bupivacaine (0.07 mg/cm); * Group F6: received a fractionated administration of the reduced dose of bupivacaine (0.06 mg/cm).
• Group B: received a bolus administration of the total dose of 0.5% hyperbaric bupivacaine (0.07 mg/cm height)
Kyiv Perinatal Center
Kyiv, Ukraine
Hemodynamic Stability (systolic, diastolic and mean arterial pressure, heart rate)
Hemodynamic parameters were recorded every 2 minutes for 10 minutes, then every 5 minutes until 30 minutes, then every 15 minutes until surgery completion.
Time frame: Perioperative/Periprocedural - before spinal anesthesia and then during the cesarean section until its completion
Spinal block characteristics (sensory block level and duration, motor block duration, analgesia duration)
Spinal block characteristics were assessed every minute for 5 minutes, then every 5 minutes until peak effect, then every 30 minutes until sensory regression to L1 dermatome and motor block regression to Bromage 0. Sensory block was assessed using pin-prick method at the midaxillary line bilaterally. Motor block was evaluated using the modified Bromage scale (0 = full motor function, 3 = complete motor block). Postoperative pain was assessed using numeric rating scale (NRS) every 30 minutes for 2 hours, then hourly for 8 hours.
Time frame: Perioperative/Periprocedural
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