This is a prospective observational study aiming to investigate the microbiome in patients suspected of having pancreatic cancer. The purpose is to enhance diagnostic accuracy by developing screening protocols for high-risk individuals, identifying specific microbial biomarkers, and improving prognostic criteria to optimize treatment response. Participants will be asked to complete a questionnaire, provide oral and fecal swabs, and-if clinically indicated-1-2 pancreatic biopsies will be collected.
Study Type
OBSERVATIONAL
Enrollment
300
Aprox. 300 patients suspected of pancreatic cancer. Of those, minimum of 50 patients with histologically confirmed PDAC in each of the stages I-II, III and IV, as some of the participants will be diagnosed with a non-malignant disease and will constitute the control group.
Herlev og Gentofte Hospital
Herlev, Capital Region, Denmark
RECRUITINGComposition of microbiota in pancreatic cancer
To examine the composition of microbiota in pancreatic cancer and its precursors, to explore association between bacterial/fungal genera and final diagnosis, survival and risk of recurrence, but also to examine a possible role of microbiota in development of surgical adverse events.
Time frame: 2037
Databank
To establish a databank containing clinical and demographic information from patients undergoing endoscopic evaluation of a pancreatic lesion
Time frame: 2037
Biobank
To establish a biobank of various biological material, herein tissue biopsies and/or cyst fluid, oral and fecal swabs at the time of inclusion and following end of therapy
Time frame: 2037
Intratumor and gut mikrobiota
To assess possible differences between intratumor and gut microbiota, and to inspect any changes in gut microbiota composition following surgery.
Time frame: 2037
Intratumor viral DNA
To investigate prevalence of intratumor viral DNA for the first time.
Time frame: 2037
Microbiome-tumor interaction
To elucidate microbiome-tumor interaction by examining intratumor gene expression and metabolism through RNA sequencing and isothermal microcalorimetry.
Time frame: 2037
Microbiome composition
To visualize microbiome composition within the tumor through fluorescence in situ hybridization confocal laser scanning microscopy and to determine geographic spread of the microbiome and its interaction with tumor cells.
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Time frame: 2037