ENX-104 MAD Study for Participants With Major Depressive Disorder With Anhedonia (aMDD)

Inclusion Criteria: * Biologically female participants (defined as assigned female at birth) 1. Of non-childbearing potential, defined as either permanently sterilized or postmenopausal and with a negative pregnancy test. 2. Of childbearing potential and willing to use both a highly effective method of contraception and a condom with any partner or remain abstinent, and with a negative pregnancy test 3. Not currently breastfeeding or lactating, and not intending to initiate breastfeeding during the course of study conduct * Biologically male participants (defined as assigned male at birth), if fertile must be willing to have a partner use a highly effective method of contraception and participant use a condom with any partner of childbearing potential, or remain abstinent Exclusion Criteria: * Unable or unwilling to comply with the requirements of the study or, in the opinion of the Investigator or Sponsor, should not participate in the study.