A Phase Ia Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Doses of EA5 in Healthy Adult Subjects

Inclusion Criteria: * Healthy subjects aged 18 to 55 years (inclusive), regardless of gender. * Body weight ≥50 kg (male) or ≥45 kg (female), and a body mass index (BMI) between 18 and 28 kg/m² (inclusive). * Must have received the meningococcal polysaccharide vaccine MenACWY (containing serogroups A, C, W, and Y) at least two weeks prior to dosing. * Subjects must be able to communicate effectively with the investigator and are expected to comply with the study procedures as defined in the protocol. * Subjects must be in good general health, as judged by the investigator based on medical history, physical examination, vital signs, electrocardiogram (ECG), chest X-ray, abdominal ultrasound, and laboratory test results. * Male subjects agree to use effective contraception (vasectomy, abstinence, or condom) from screening until 6 months after the final study intervention. Female subjects must have a negative blood pregnancy test at screening and baseline. Throughout the study and for 6 months thereafter, all subjects and their partners (if of childbearing potential) must use highly effective non-pharmacological contraception. * Subjects must provide written informed consent voluntarily before any study-specific procedures are performed. * Systolic and diastolic blood pressure must be within the normal range, or exhibit abnormalities deemed clinically insignificant by the investigator. Exclusion Criteria: * History of severe drug allergy; or a clear history of allergy and/or known allergy to the investigational product or any of its excipients, which in the opinion of the investigator, renders the subject unsuitable for participation in the study. * Prior history of splenectomy. * History of pulmonary tuberculosis. * Congenital or acquired complement deficiency (e.g., hypocomplementemia). * Any contraindication to antibiotic prophylaxis (e.g., beta-lactam antibiotics, ciprofloxacin) for meningococcal infection * Positive test for hepatitis C virus (HCV) antibody, human immunodeficiency virus (HIV) antibody, treponemal antibody (TP-Ab), or hepatitis B virus (HBV) surface antigen (HBsAg) at screening * Presence of symptoms or a significant history of any major disease, including but not limited to cardiac, hepatic, renal, other acute or chronic gastrointestinal or respiratory diseases; hematological, endocrine, neurological, psychiatric disorders; or any other disease or physiological condition that could interfere with the interpretation of the study results. * Participation in any clinical trial involving an investigational drug or medical device within 3 months prior to screening, or within 5 half-lives of the previous investigational drug prior to screening (whichever is longer) * Blood loss or donation \> 400 mL within 3 months prior to screening, or \> 200 mL within 4 weeks prior to screening, or intention to donate blood during the study period * Average cigarette smoking of ≥5 cigarettes per day within 3 months prior to the study * Alcohol abuse or regular alcohol consumption exceeding 14 units per week within 6 months prior to screening (1 unit ≈ 360 mL beer, 45 mL 40% spirits, or 150 mL wine), or a positive alcohol breath test at screening. * History of drug abuse or a positive urine drug screen at screening * Undergone surgery or received blood or blood product transfusion within 1 month prior to screening。 * Administration of any live or live-attenuated vaccine within 1 month prior to the first dose。 * Use of any prescription drugs, over-the-counter medications, herbal medicines, or vitamins within 14 days or 5 half-lives (whichever is longer) prior to screening。 * Presence of any active infection (viral, bacterial, or fungal), including herpes zoster or herpes simplex, within 14 days prior to dosing. * History of fever (≥38°C) within 7 days prior to the first dose. * Female subjects who are pregnant or lactating, or who have engaged in unprotected sexual intercourse within 14 days prior to the study. * Inability to complete the study for any other reason, or considered by the investigator to be unsuitable for inclusion.