Toripalimab Combined With Anthracycline-free or Anthracycline-containing Chemotherapy as Neoadjuvant Chemotherapy for Early Triple Negative Breast Cancer

Inclusion Criteria: 1. Age: 18-70 years. 2. Disease Status: Clinical pathological confirmation of cT2-cT4d, or cT1c with axillary lymph node metastasis. 3. Pathology: Histopathologically confirmed triple-negative, invasive breast carcinoma. 4. Definition of Triple-Negative Breast Cancer: 5. ER and PR negative (IHC nuclear staining \<10%). 6. Her-2 negative (IHC 0 or 1+ without FISH, or IHC 2+ with FISH demonstrating no amplification). 7. Measurable Disease: Presence of clinically measurable lesion(s) confirmed by ultrasound, mammography, or optional MRI within 1 month prior to randomization. 8. Adequate Organ and Bone Marrow Function (within 1 month prior to chemotherapy), indicating no contraindications for chemotherapy: 9. Absolute Neutrophil Count (ANC) ≥ 1.5 × 10⁹/L 10. Hemoglobin (Hb) ≥ 90 g/L 11. Platelet count (PLT) ≥ 100 × 10⁹/L 12. Total Bilirubin (TBIL) \< 1.5 × ULN (Upper Limit of Normal) 13. Serum Creatinine (Cr) \< 1.5 × ULN 14. Aspartate Aminotransferase (AST) / Alanine Aminotransferase (ALT) \< 1.5 × ULN 15. Cardiac Function: Left ventricular ejection fraction (LVEF) ≥ 50% as measured by echocardiogram. 16. Pregnancy Status: For women of childbearing potential, a negative serum pregnancy test within 14 days prior to randomization. 17. Performance Status: Eastern Cooperative Oncology Group (ECOG) performance status score of ≤ 1. 18. Informed Consent: Signed informed consent obtained. Exclusion Criteria: 1. Metastatic Disease: Evidence of metastatic breast cancer. (To exclude metastasis, CT scans of the chest and abdomen, and a bone scan must be performed at any time point from diagnosis to randomization; PET/CT may serve as an alternative imaging modality). 2. Prior Anti-Cancer Therapy: Any prior chemotherapy, endocrine therapy, targeted therapy, or radiotherapy for the current breast cancer. 3. Second Primary Malignancy: Presence of a second primary malignancy, except for: 4. Adequately treated non-melanoma skin carcinoma. 5. Prior Immunotherapy: Previous treatment with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent, or any other immunomodulatory therapy. 6. Immunodeficiency or Autoimmune Disease: Diagnosed immunodeficiency or active autoimmune disease requiring systemic treatment. 7. Severe Comorbidities: Severe or uncontrolled pulmonary or cardiac disease. 8. Active Hepatitis: Active Hepatitis B or Hepatitis C infection. 9. Transplantation History: History of solid organ or bone marrow transplantation. 10. Pregnancy/Lactation: Pregnant or lactating women. 11. Other Medical Conditions: Any other severe, uncontrolled medical condition that, in the investigator's judgment, constitutes a contraindication to chemotherapy.