RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis

University of Maryland, Baltimore10 enrolled

Overview

Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring. It can be secondary to iatrogenic etiologies such as intubation or tracheostomy , as well as autoimmune diseases and being idiopathic. Patients typically undergoes endoscopic or surgical interventions to open up the airways. This project will analyze resected or biopsied tissue from patients with benign tracheal stenosis to define disease-specific RNA expression profiles.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Tracheal Stenosis Subglottic Stenosis

Interventions

Biopsy or surgeryPROCEDURE

The tissue will be obtained from biopsy or surgical resection. All the "intervention" will be performed for clinical needs. The tissue used in the study will be considered as discarded tissue

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with benign tracheal stenosis Exclusion Criteria: * Malignancy. active infection

Locations (1)

University of Maryland

Baltimore, Maryland, United States

RECRUITING

Outcomes

Primary Outcomes

RNA profile

The diseased mucosa will show a increased fibrosis and inflammation profile compared with that from normal mucosa

Time frame: 1 year

Central Contacts

Chenchen Zhang, MD

CONTACT

14103288141 chenchen.zhang@som.umaryland.edu

Data from ClinicalTrials.gov

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