This study aims to investigate the effect of a VExUS ultrasound guided protocol of perioperative fluid management within a goal-directed therapy framework, on postoperative respiratory complications, and the occurrence of acute kidney injury (AKI) in patients undergoing thoracic surgery.
In thoracic surgery, intraoperative fluid management presents a challenge for anesthesiologists, as patients are at high risk of developing interstitial and alveolar edema of the lungs. A history of pulmonary disease, previous chemotherapy or radiation therapy in the area, one-lung ventilation, surgical manipulation, and ischemia-reperfusion injury can all damage the respiratory epithelium's glycocalyx, the alveolar epithelium, and surfactant, ultimately leading to pulmonary injury. These factors, combined with liberal perioperative fluid management, increase the risk of acute respiratory distress syndrome (ARDS), atelectasis, pneumonia, and ultimately postoperative mortality. Traditionally, a restrictive fluid management strategy is employed intraoperatively, with crystalloid administration at a rate of 1-2 ml/kg/h, ensuring that the perioperative fluid balance does not exceed 1500 ml. This restrictive strategy may increase the risk of hypovolemia, which can lead to tissue hypoperfusion, target organ dysfunction, and acute kidney injury. Within the Enhanced Recovery After Surgery (ERAS) protocols, goal-directed therapy (GDT) for fluid management in thoracic surgery is discussed but not explicitly recommended. Recommendations include avoiding overly restrictive or completely liberal fluid strategies, maintaining euvolemia, and preventing tissue hypoperfusion with balanced use of inotropic agents and fluid administration. Pulmonary injury is the leading cause of death following thoracic surgery. Pre-existing respiratory disease, surgical manipulation, lung parenchyma resection, and the detrimental effects of one-lung ventilation increase the risk of postoperative respiratory complications. Although overhydration and ventilation with high tidal volumes have been replaced by a restrictive fluid strategy and the application of protective mechanical ventilation, it appears that all factors involved in ventilator-induced lung injury (VILI) also play a harmful role in one-lung ventilation. High strain on the ventilated lung, oxidative stress, surgical trauma, recruitment maneuvers, biological trauma, atelectatic trauma, and ischemia-reperfusion injury are the pathophysiological mechanisms leading to postoperative acute respiratory failure and, in 2-5% of cases, to ARDS. Postoperative acute kidney injury (AKI) represents 18-47% of in-hospital AKI and is associated with prolonged hospitalization and high morbidity and mortality. Recently, the implementation of new AKI classifications (RIFLE, AKIN, KDIGO) has facilitated its early recognition for immediate preventive measures. Additionally, the detection of two early urinary biomarkers of kidney stress, the tissue inhibitor of metalloproteinases-2 (TIMP-2) and the insulin-like growth factor-binding protein 7 (IGFBP7), has contributed to this. Postoperatively, an increase in serum creatinine by up to 0.5 mg/dL from baseline has been associated with a threefold increase in mortality following cardiac surgery. Potential pathophysiological mechanisms of postoperative AKI include ischemia, inflammation, and toxins. However, in thoracic surgeries, both the hypovolemia of a restrictive fluid administration strategy and overhydration and venous congestion can equally lead to acute kidney injury postoperatively. The VExUS protocol is a standardized point-of-care ultrasound examination that includes measurements of the inferior vena cava (IVC) diameter, combined with Doppler analysis of waveforms in the hepatic vein, portal vein, and renal veins. From this analysis, the presence of venous congestion-classified as mild or severe-or its absence is determined. A high VExUS score (grade 3) has been strongly associated with the occurrence of acute kidney injury in patients undergoing cardiac surgery and has more recently been linked to elevated right atrial pressure (RAP ≥ 12 mmHg). The protocol includes the following classification: Grade 0: IVC \< 2 cm Grade 1: IVC ≥ 2 cm, with normal or mildly abnormal waveforms in the hepatic, portal, and renal veins (mild congestion) Grade 2: IVC ≥ 2 cm, with severely altered waveforms in at least one vein (moderate congestion) Grade 3: IVC ≥ 2 cm, with severely altered waveforms in multiple veins (severe congestion). A single-center clinical study conducted in the Anesthesiology Clinic of the University General Hospital of Heraklion. Parallel design in two groups.Preoperative assessment, fasting, and premedication according to the routine of the department: * Discontinuation of fluid intake 2 hours before surgery * cessation of food intake 6 hours preoperatively * discontinuation on the day of surgery of ACE inhibitors, angiotensin receptor blockers, thiazide diuretics, and loop diuretics. Upon entering the operating room, patients will be connected standard ASA monitors: 5 lead ECG, pulse oximetry (SpO2), non-invasive blood pressure measurement. Under local anaesthesia an arterial catheter will be placed for invasive blood pressure measurement and blood gas sampling, along with at least two venous catheters of 16-20 G. Anesthesia and postoperative analgesia management will depend solely on the discretion of the responsible anesthesiologist. After anesthesia induction and double-lumen endotracheal tube placement, patients will be connected to the anesthesia machine, recruitment maneuvers will be performed with PEEP titration, and they will be mechanically ventilated applying the principles of protective mechanical ventilation. The correct placement of the endotracheal tube will be confirmed with fiberoptic bronchoscopy immediately after placement. A urinary catheter will be placed for hourly urine measurement, along with a thermometer. Intraoperatively, the total administered fluids, hourly urine output, type and dose of vasopressor medications, and blood pressure (SAP, DAP, MAP) will be recorded every 15 minutes (unless a significant change occurs), along with arterial blood gases and lactate. Protective Mechanical Ventilation of One Lung: Ventilated lung: Tidal volume (Vt): 4-5 ml/kg ideal body weight, Appropriate PEEP of 5-15 cmH2O, possible repeat of recruitment maneuver Plateau pressure - PEEP: up to 15 cmH2O, Management of respiratory rate (RR) aiming for permitted mild hypercapnia (PaCO2 = 40-60 mmHg), Modification of the I ratio to avoid air trapping and the emergence of PEEPi, Titration of FiO2 to achieve SpO2 = 88-92%, Protection against hypoxic pulmonary vasoconstriction by avoiding vasodilators, hypoventilation, alkalosis, hypothermia, and if inhaled anesthetics are used, maintaining MAC \< 1, Mechanical ventilation model: Volume Control- Auto Flow on the Perseus A500 and Atlan A350 machines from Drager available in the Anesthesia Clinic. Non-ventilated lung with SpO2 \< 88%: Recruitment maneuvers with the use of PEEP if possible, Use of CPAP, FiO2 = 100% and cessation of one lung ventilation. Control Group: Intraoperatively patients of the control group will be administered isotonic crystalloids (Lactated Ringer's, Plasma-Lyte) at a rate of 3 mL/kg/h. VExUS-guided Group: VExUS Evaluation. The VExUS evaluation will be performed pre- and immediately post-intubation before one-lung ventilation initiation. A trained anesthesiologist (will evaluate the patient according to the VExUS protocol, measuring the IVC diameter and performing Doppler analysis of the hepatic, portal, and renal veins. A VExUS score will be assigned as outlined in the section above. Ultrasound monitoring will be performed according to the VExUS protocol before positioning the patient in the lateral decubitus position. In patients with VExUS grade 0, a bolus of 250-500 mL (approximately 3 mL/kg) will be administered, followed by the infusion of crystalloids at a rate of 3 mL/kg/h. The inferior vena cava (IVC) diameter will be measured three times: once prior to anesthesia induction, once immediately after intubation, and once before patient emergence from anesthesia. In patients with VExUS grade 1, no bolus will be given, and only a fluid infusion at 3 mL/kg/h will be administered. In patients with VExUS grades 2 and 3, 10 mg of furosemide will be administered intravenously, followed by crystalloids infusion at a rate of 2 mL/kg/h. In both groups, blood losses will be replaced with a 5% albumin solution at a 1:1 ratio. Transfusion will be administered to maintain hemoglobin levels at 9 mg/dL. Both groups will follow the same multimodal anesthesia-analgesia protocol, with restricted opioid use in accordance with the departmental routine. Intraoperative hypotension (systolic arterial pressure \< 90 mmHg or a decrease \> 20% from baseline) will be managed with titrated norepinephrine infusion. Post-Anesthesia Care Unit (PACU) Control Group: Fluid administration will continue at a rate of 3 mL/kg/h as per standard practice. VExUS-guided Group: VExUS ultrasound will be repeated postoperatively. In patients with VExUS grade 0, a bolus of 250-500 mL (approximately 3 mL/kg) will be administered, followed by the infusion of crystalloids at a rate of 3 mL/kg/h. In patients with grades 1 to 3, 10 mg of intravenous furosemide will be administered, followed by a fluid infusion at 3 mL/kg/h and reassessment. Patients will be monitored daily for the occurrence of postoperative respiratory complications as defined by the European Society of Anaesthesiology. Preoperative blood gas values (PaO2, PaCO2) will be measured as baseline, and postoperative blood gases will be collected on the 1st and 3rd postoperative days in the PACU. Oxygenation will be assessed using the PaO2/FiO2 ratio, and lactate levels will be measured concurrently. Additionally, for each patient, estimated glomerular filtration rate (eGFR) using serum creatinine, cystatin C or both will be calculated preoperatively and on the 1st and 3rd postoperative days in PACU. To assess acute kidney injury (AKI), serum creatinine and cystatin C will be measured on the 1st and 3rd postoperative days, and AKI diagnosis and classification will follow KDIGO (Kidney Disease Improving Global Outcomes) criteria. The following kidney injury biomarkers will also be measured: Serum cystatin C, Total urine protein and albumin, Urine beta-2 microglobulin, Urine creatinine. Kidney stress biomarkers TIMP-2 and IGFBP7 in urine, as described above, will be measured immediately postoperatively in the PACU. These biomarkers will also be measured in the PACU and on the 1st and 3rd postoperative days.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
230
The VExUS protocol is a standardized point-of-care ultrasound examination that includes measurements of the inferior vena cava (IVC) diameter, combined with Doppler analysis of waveforms in the hepatic vein, portal vein, and renal veins. From this analysis, the presence of venous congestion-classified as mild or severe-or its absence is determined. A high VExUS score (grade 3) has been strongly associated with the occurrence of acute kidney injury in patients undergoing cardiac surgery and has more recently been linked to elevated right atrial pressure (RAP ≥ 12 mmHg). The protocol includes the following classification: * Grade 0: IVC \< 2 cm * Grade 1: IVC ≥ 2 cm, with normal or mildly abnormal waveforms in the hepatic, portal, and renal veins (mild congestion) * Grade 2: IVC ≥ 2 cm, with severely altered waveforms in at least one vein (moderate congestion) * Grade 3: IVC ≥ 2 cm, with severely altered waveforms in multiple veins (severe congestion)
Intraoperatively patients of the control group will be administered isotonic crystalloids (Lactated Ringer's, Plasma-Lyte) at a rate of 3 mL/kg/h.Fluid administration will continue at a rate of 3 mL/kg/h as per standard practice in the PACU.
University General Hospital of Heraklion
Heraklion, Crete, Greece
RECRUITINGKidney function-estimated glomerular filtration rate preoperatively
Estimated glomerular filtration rate (eGFR) using serum creatinine, cystatin C or both calculated by CKD-EPI 2021 and MDRD equation
Time frame: preoperatively
Kidney function-estimated glomerular filtration rate in the PACU
Estimated glomerular filtration rate (eGFR) using serum creatinine, cystatin C or both calculated by CKD-EPI 2021 and MDRD equation
Time frame: in the PACU
Kidney function- estimated glomerular filtration rate on postoperative day 1
Estimated glomerular filtration rate (eGFR) using serum creatinine, cystatin C or both calculated by CKD-EPI 2021 or MDRD equation.
Time frame: postoperative day 1
Kidney function-estimated glomerular filtration rate on postoperative day 3
Estimated glomerular filtration rate (eGFR) using serum creatinine, cystatin C or both calculated by tha CKD-EPI 2021 and MDRD equation
Time frame: on postoperative day 3
Urine output intraoperatively
Kidney function as quantified by urine output. Data will be reported as an averaged intraoperative rate in ml/kg\*h.
Time frame: From anesthesia induction, until the end of surgery
Urinary output postoperatively in the PACU
Kidney function as quantified by urine output. Data will be reported as an averaged intraoperative rate in ml/kg\*h.
Time frame: during the PACU stay
Renal stress biomarkers TIMP-2,IGFBP-7
The detection of two early urinary biomarkers of kidney stress, the tissue inhibitor of metalloproteinases-2 (TIMP-2) and the insulin-like growth factor-binding protein 7 (IGFBP7), has contributed to early diagnosis of AKI and renal stress.Urine sample collection will take place in both study groups.
Time frame: postoperatively in the PACU
Serum Creatinine preoperatively
Baseline serum creatinine measurement, in mg/dl.Blood sample collection will take place in both study groups.
Time frame: preoperatively
Serum creatinine in the PACU
serum creatinine measurement, in mg/dl.Blood sample collection will take place in both study groups.
Time frame: during the PACU stay
Serum creatinine on postoperative day 1
Serum creatine measurement in mg/dlBlood sample collection will take place in both study groups.
Time frame: postoperative day 1
Serum creatinine on postoperative day 3
measurement of serum creatinine in mg/dl.Blood sample collection will take place in both study groups.
Time frame: postoperative day 3
Serum cystatin C preoperatively
baseline measurement of serum cystatin C in mg/L.Blood sample collection will take place in both study groups.
Time frame: preoperatively
serum cyctatin C in the PACU
measurement of serum cystatin C postopertively in the PACU.Blood sample collection will take place in both study groups.
Time frame: during the PACU stay
serum cystatin C on postoperative day 1
measurement of serum cystatin C in mg/L.Blood sample collection will take place in both study groups.
Time frame: postoperative day 1
serum cystatin C on postoperative day 3
measurement of serum cystatin C in mg/LBlood sample collection will take place in both study groups.
Time frame: postoperative day 3
urine beta-2 microglobulin preoperatively
baseline measurement of beta-2 microglobulin in urine, as a renal stress marker.Urine sample collection will take place in both study groups.
Time frame: preoperatively
urine beta-2 microglobulin in the PACU
measurement of beta-2 microglobuline in urine.Urine sample collection will take place in both study groups.
Time frame: during the PACU stay
urine beta-2 microglobulin on postoperative day 1
measurement of beta-2 microglobulin in urine.Urine sample collection will take place in both study groups.
Time frame: postoperative day 1
urine beta-2 microglobulin on postoperative day 3
measurement of beta-2 microglobulin in urine.Urine sample collection will take place in both study groups.
Time frame: postoperative day 3
total urine protein preoperatively
baseline total urine protein measurement in mg/L in both groups of patients
Time frame: preoperatively
total urine protein in the PACU
Measurement of total urine protein in mg/l in both groups of patients
Time frame: during the PACU stay
total urine protein on postoperative day 1
total urine protein measurement in mg/L in both groups of patients
Time frame: postoperative day 1
total urine protein on postoperative day 3
measurement of total urine protein in mg/L in both groups of patients
Time frame: postoperative day 3
urine albumin preoperatively
baseline measurement of urine albumin in both groups of patients
Time frame: preoperatively
urine albumin in the PACU
urine albumin measurement in both groups of patients
Time frame: during the PACU stay
urine albumin on postoperative day 1
measurement of urine albumin in both groups of patients
Time frame: postoperative day 1
urine albumin on postoperative day 3
measurement of urine albumin in both groups of patients
Time frame: postoperative day 3
urine creatinine preoperatively
urine creatinine baseline measurement in g/L in both groups of patients
Time frame: preoperatively
urine creatinine in the PACU
urine creatinine measurement in g/L in both groups of patients
Time frame: during the PACU stay
urine creatinine on postoperative day 1
measurement of urine creatinine in g/l in both groups of patients
Time frame: postoperative day 1
urine creatinine on postoperative day 3
measurement of urine creatinine in g/l in both groups of patients
Time frame: postoperative day 3
urine albumin to creatinine ratio preoperatively
baseline measurement of urine albumin to creatinine ratio in both groups of patients
Time frame: preoperatively
urine albumin to creatinine ratio in the PACU
measurement of urine albumin to creatinine ratio in both groups of patients
Time frame: during the PACU stay
urine albumin to creatinine ratio on postoperative day 1
measurement of urine albumin to creatinine ratio in both groups of patients
Time frame: postoperative day 1
urine albumin to creatinine ratio on postoperative day 3
measurement of urine albumin to creatinine ratio in both groups of patients
Time frame: postoperative day 3
urine protein to creatinine ratio preoperatively
baseline measurement of urine protein to creatinine ratio in both groups of patients
Time frame: preoperatively
urine protein to creatinine ratio in the PACU
measurement of protein to creatinine ratio in both groups of patients
Time frame: during the PACU stay
urine protein to creatinine ratio on postoperative day 1
measurement of protein to creatinine ratio in both groups of patients
Time frame: postoperative day 1
urine protein to creatinine ratio on postoperative day 3
measurement of protein to creatinine ratio in both groups of patients
Time frame: postoperative day 3
pulse oximetry (SpO2) preoperatively
baseline pulse oximetry measurement in both groups of patients
Time frame: preoperatively
pulse oximetry (SpO2) intraoperatively
mean of pulse oximetry measurements in both groups of patients
Time frame: during one lung ventilation
pulse oximetry (SpO2) in the PACU
mean of pulse oximetry measurements in both groups of patients
Time frame: during the PACU stay
pulse oximetry (SpO2) on postoperative day 1
pulse oximetry measurement in both groups of patients
Time frame: postoperative day 1
pulse oximetry (SpO2) on postoperative day 3
pulse oximetry measurement in both groups of patients
Time frame: postoperative day 3
arterial oxygen saturation (SaO2) preoperatively
baseline measurement of arterial oxygen saturation in both groups of patients by arterial blood gas analysis
Time frame: preoperatively
arterial oxygen saturation (SaO2) intraoperatively
mean of measurement of arterial oxygen saturation in both groups of patients by arterial blood gas analysis
Time frame: intraoperatively
arterial oxygen saturation (SaO2) in the PACU
mean of measurement of arterial oxygen saturation in both groups of patients by arterial blood gas analysis
Time frame: during the PACU stay
arterial oxygen saturation (SaO2) on postoperative day 1
measurement of arterial oxygen saturation in both groups of patients by arterial blood gas analysis
Time frame: postoperative day 1
arterial oxygen saturation (SaO2) on postoperative day 3
measurement of arterial oxygen saturation in both groups of patients by arterial blood gas analysis
Time frame: postoperative day 3
arterial carbon dioxide partial pressure (PaCO2) preoperatively
baseline measurement of arterial carbon dioxide partial pressure in mmHg in both groups of patients
Time frame: preoperatively
arterial carbon dioxide partial pressure intraoperatively
mean of arterial carbon dioxide partial pressure measurements in mmHg in both groups of patients
Time frame: intraoperatively
arterial carbon dioxide partial pressure in the PACU
mean of arterial carbon dioxide partial pressure measurements in mmHg in both groups of patients
Time frame: during the PACU stay
arterial carbon dioxide partial pressure on postoperative day 1
arterial carbon dioxide partial pressure measurement in mmHg in both groups of patients
Time frame: postoperative day 1
arterial carbon dioxide partial pressure on postoperative day 3
arterial carbon dioxide partial pressure measurement in mmHg in both groups of patients
Time frame: postoperative day 3
arterial oxygen partial pressure (PaO2) preoperatively
arterial oxygen partial pressure baseline measurement in mmHg in both groups of patients
Time frame: preoperatively
arterial oxygen partial pressure (PaO2) intraoperatively
mean of arterial oxygen partial pressure measurements in mmHg in both groups of patients during one lung ventilation
Time frame: intraoperatively
arterial oxygen partial pressure (PaO2) in the PACU
mean of arterial oxygen partial pressure measurements in mmHg in both groups of patients
Time frame: during the PACU stay
arterial oxygen partial pressure (PaO2) on postoperative day 1
arterial oxygen partial pressure measurement in mmHg in both groups of patients
Time frame: postoperative day 1
arterial oxygen partial pressure (PaO2) on postoperative day 3
arterial oxygen partial pressure measurement in mmHg in both groups of patients
Time frame: postoperative day 3
arterial lactate measurement preoperatively
baseline measurement of arterial lactate in mmol/L by arterial blood gas analysis in both groups of patients
Time frame: preoperatively
arterial lactate measurement intraoperatively
mean of measurements of arterial lactate in mmol/L by arterial blood gas analysis in both groups of patients
Time frame: intraoperatively
arterial lactate measurement in the PACU
mean of measurements of arterial lactate in mmol/L by arterial blood gas analysis in both groups of patients
Time frame: during the PACU stay
arterial lactate measurement on postoperative day 1
measurement of arterial lactate in mmol/L by arterial blood gas analysis in both groups of patients
Time frame: postoperative day 1
arterial lactate measurement on postoperative day 3
measurement of arterial lactate in mmol/L by arterial blood gas analysis in both groups of patients
Time frame: postoperative day 3
oxygen partial pressure to fraction of oxygen in inspired air ratio (P/F ratio) in arterial blood preoperatively
baseline measurement of P/F ratio by arterial blood gas analysis in both groups of patients
Time frame: preoperatively
oxygen partial pressure to fraction of oxygen in inspired air ratio (P/F ratio) in arterial blood intraoperatively
mean of measurements of P/F ratio by arterial blood gas analysis in both groups of patients
Time frame: intraoperatively
oxygen partial pressure to fraction of oxygen in inspired air ratio (P/F ratio) in arterial blood in the PACU
mean of measurements of P/F ratio by arterial blood gas analysis in both groups of patients
Time frame: during the PACU stay
oxygen partial pressure to fraction of oxygen in inspired air ratio (P/F ratio) in arterial blood on postoperative day 1
measurement of P/F ratio by arterial blood gas analysis in both groups of patients
Time frame: postoperative day 1
oxygen partial pressure to fraction of oxygen in inspired air ratio (P/F ratio) in arterial blood on postoperative day 3
measurement of P/F ratio by arterial blood gas analysis in both groups of patients
Time frame: postoperative day 3
occurrence of postoperative pulmonary complications (PCCs) on postoperative day 1
Patients will be monitored for the occurrence of postoperative respiratory complications as defined by the European Society of Anaesthesiology, including aspiration pneumonitis, respiratory failure, ARDS, pulmonary infection, atelectasis, cardiopulmonary edema, pleural infusion, pneumothorax, pulmonary infiltrates, prolonged air leakage, purulent pleuritis, pulmonary embolism, lung hemorrhage and bronchospasm. Chest radiography obtaining on postoperative day 1, arterial blood gas analysis as already mentioned and clinical findings such as respiratory rate, heart rate, blood pressure, temperature, airway secretions, Visual analog scale of dyspnea will help to identify the presence or not of PCCs.
Time frame: on postoperative day 1
occurrence of postoperative pulmonary complications (PCCs) on postoperative day 3
Patients will be monitored for the occurrence of postoperative respiratory complications as defined by the European Society of Anaesthesiology, including aspiration pneumonitis, respiratory failure, ARDS, pulmonary infection, atelectasis, cardiopulmonary edema, pleural infusion, pneumothorax, pulmonary infiltrates, prolonged air leakage, purulent pleuritis, pulmonary embolism, lung hemorrhage and bronchospasm. Chest radiography obtaining on postoperative day 3 or earlier, arterial blood gas analysis as already mentioned and clinical findings such as respiratory rate, heart rate, blood pressure, temperature, airway secretions, Visual analog scale of dyspnea will help to identify the presence or not of PCCs.
Time frame: on postoperative day 3
long term kidney impairment
serum and urine creatinine, serum urea, urine albumin and protein and consequently albumin to creatinine ratio and protein to creatinine ratio will be measured approximately 30 days postoperative, to asses long term renal dysfunction after VATS lobectomy.
Time frame: from enrollment to day 30 approximately
Noradrenaline equivalent dose
Both groups maintained stable blood pressures with norepinephrine support as needed, but VExUS group showed more hemodynamic stability, concerning the measurements of cardiac output, cardiac index, stroke volume and stroke volume variation ( pulse contour analysis). As though, a larger noradrenaline amount as total dose and consequently, a bigger noradrenaline equivalent dose is expected to be given perioperatively in the control group of standard of care.
Time frame: from the surgery onset to the discharge from the post anesthesia care unit
Length of stay - Hospital Discharge
Hospital length of stay will be reported in days.
Time frame: From date of randomization (day before surgery) until the date of the discharge from the hospital
intraoperative hypotension
Intraoperative Hypotension (defined as MAP≤65mmHg or ≤80% of preoperative Baseline), with episodes lasting ≥1 minute. All patients will have a 5 minute preoperative MAP baseline, with measurements every 20 seconds. Intraoperative data will be compared to the mean preoperative 5 minute MPB baseline.
Time frame: Baseline: 5 minutes prior to anaesthesia induction. Intraoperative Hypotension: From anesthesia induction, until the end of surgery
hemodynamic stability: pulse contour analysis monitoring
During the operation, a cardiac output monitor with waveform analysis will be used, providing calculations every 20 seconds for CO, CI, SV, SVI, SVV, SAP, DAP, MAP, and PR, without any decisions regarding fluid administration being made based on these measurements. In the control group, fluid administration will be fixed at 3 ml/kg/h, while in the VExUS group, fluid administration will be guided by the ultrasound protocol. Episodes of hypotension will be managed accordingly with the administration of vasoconstrictive drugs.These data will be used to compare the hemodynamic stability between the two groups.
Alexandros Bogas Manouselis, Resident of Anaesthesiology
CONTACT
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Time frame: Baseline: 5 minutes prior to anaesthesia induction.From anesthesia induction, until the end of surgery
RBCs tranfusion, FFP transfusion, PLT tranfusion intraoperatively
Concentrated RBC, FFP, PLT unit requirements. Data will be reported in ml.
Time frame: From anesthesia induction, until the end of surgery