Feasibility and Safety of Blood-Flow-Restriction Training in Patients With Hemophilia

N/AEnrolling By InvitationNCT07259356

University Hospital, Bonn12 enrolled

Overview

In the course of a cross-over study design, 12 patients with hemophilic arthropathy will perform a training load on the knee extensor muscles. The subjects will each perform one intervention with blood flow restriction and one with a Sham-BFR intervention.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Hemophilia

Interventions

ControlDEVICE

Sham-BFR Exercise (20mmHg) while Leg Press Exercise (4 Sets, All out)

BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)DEVICE

BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with haemophilia * Ability for an exercise intervention Exclusion Criteria: * Sickle Cell Anemia * Intravascular stents/bypasses * Open Wounds/Infections of the lower extremity

Locations (1)

University Hospital Bonn

Bonn, North Rhine-Westphalia, Germany

Outcomes

Primary Outcomes

Pain threshold

Pain threshold measurement (PTT): The test determines the amount of pressure (in kg) over a given area in which a steadily increasing nonpainful pressure stimulus turns into a painful pressure sensation.

Time frame: Pre- (Baseline, before Exercise) to immediately Post-Intervention (after the exercise training intervention) and 24 hours after intervention

Quality of Life Score

Hemophilia Joint Health Score

Time frame: Pre- (Baseline, before Exercise) to immediately Post-Intervention (after the exercise training intervention) and 24 hours after intervention

Data from ClinicalTrials.gov

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