Fasting is a requirement to safely anesthetise patients referred for elective procedure, using the traditional 6/4/2 rule (6h for solid food or formula milk, 4h for breast milk and 2h for clear fluids), applied to all patients regardless of their age or weight. Reducing the aspiration risk however puts young children at higher risk of hypoglycemia due to the immaturity of their endocrine system and absence of metabolic reserves. The Association of Paediatric Anaesthetists of Great Britain and Ireland recommends that during day case surgery the majority of children may be given fluids without dextrose, provided blood glucose is monitored. Recent statements recommend continuing fluids until 1h before the procedure or even to give fluids when anesthetists sent for the patients. Hypoglycemia is rare in children above 2 years of age. Although the definition of hypoglycemia can differ, a threshold of 3.6mmol/l is often used given the potential neurological harm existing below this value. There is no consensus on the definition of hypoglycemia in children being fasted prior to general anesthesia, nor when nor how to treat it. Measurements are done for complex surgeries or patients deemed at risk according to the anesthetists. An audit was run in 2017 at the " Evelina London Children's Hospital ", Guy's and St Thomas' National Health Service Foundation Trust, identifying 8% of children below 2 years of age as hypoglycemic. Recent review of our Incident Reporting Systems identified 3 cases, in otherwise fit and healthy children, referred for colonoscopy with initial hypoglycemia followed by rebound hypoglycemia after management. There is an urgent need to establish a clear definition of hypoglycemia and investigate risk factors in paediatric patients referred for elective procedures under general anesthesia.
Study Type
OBSERVATIONAL
Enrollment
6,580
Royal Devon University Healthcare NHS Foundation Trust
Exeter, Devon, United Kingdom
RECRUITINGMoorfields Eye Hospital
London, United Kingdom
COMPLETEDEvelina London Children's Hospital
London, United Kingdom
RECRUITINGClinical definition if hypoglycemia
Blood glucose values triggering a response from the anaesthetists with initiation of a hypoglycaemia treatment following a blood glucose measurement during anaesthetic induction
Time frame: Immediately/within five minutes after anesthesia induction
4mmol/l as a suitable threshold of hypoglycemia
Number of patient with a blood glucose measurement below 4mmol/l and being treated as hypoglycaemic by an anaesthetist following a blood glucose measurement during anaesthetic induction
Time frame: Immediately/within five minutes after anesthesia induction
Distribution of glycemic measurements in fasting children
Blood glucose values in children undergoing elective procedure under general anaesthesia.
Time frame: Immediately/within five minutes after anesthesia induction
Age as a risk factor of hypoglycaemia
Number of children below 24 months of age reported as hypoglycaemic by an anaesthetist following a blood glucose measurement during anaesthetic induction
Time frame: Immediately/within five minutes after anesthesia induction
Weight as a risk factor of hypoglycaemia
Number of children weighing less than 10kg and considered as hypoglycaemic by an anaesthetist following a blood glucose measurement during anaesthetic induction
Time frame: Immediately/within five minutes after anesthesia induction
Distribution of blood ketone measurements in children fasting
Blood ketone values in children undergoing elective procedure under general anaesthesia.
Time frame: Immediately/within five minutes after anesthesia induction
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