Association Between Preoperative Health and Functional Status and Postoperative Complications in Elderly Patients

Chinese PLA General Hospital8,751 enrolled

Overview

Using prospectively collected clinical data from the Chinese Perioperative Database of Elderly Patients, this study retrospectively analyzed patients aged ≥65 years who underwent elective non-cardiac, non-neurosurgical procedures under general anesthesia between April 2020 and April 2022. The study examined the associations between various preoperative health and functional status assessment tools and the occurrence of cardiovascular and cerebrovascular complications within 30 days after surgery, aiming to compare the clinical value of different assessment instruments.

Study Type

OBSERVATIONAL

Enrollment

8,751

Conditions

Functional Status Postoperative Complications Older Adults (65 Years and Older)

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion criteria: 1. Aged ≥65 years; 2. Scheduled for elective non-cardiac, non-neurosurgical procedures; 3. Consented to undergo preoperative functional status and quality of life assessments. Exclusion criteria: 1. Had severe dementia, language disorders, significant hearing or visual impairments, or were in a coma; 2. Had Mini-Mental State Examination (MMSE) scores below the established educational thresholds: \<18 for illiterate individuals, \<21 for those with primary education (≤6 years), and \<25 for those with secondary education or higher (\>6 years); 3. Underwent local anesthesia or monitored anesthesia care; 4. Had an operative time ≤30 minutes; 5. Incompleted all the designated functional status and quality of life assessments.

Outcomes

Primary Outcomes

The primary outcome was the occurrence of MACCE within 30 days after surgery.

The primary outcome was the occurrence of MACCE within 30 days after surgery, defined as any of the following: stroke, myocardial infarction, angina pectoris, congestive heart failure, cardiac arrest, or all-cause mortality.\[33\] Postoperative complications were systematically assessed on days 1-5, 7, and 30, and continued until discharge. For discharged patients, outcomes were recorded via telephone follow-up, with diagnoses from the treating hospital. For MACCE, postoperative medical records of hospitalized patients were thoroughly reviewed according to the follow-up schedule, including serial measurements of serum myocardial injury biomarkers, electrocardiograms, echocardiograms, coronary angiography findings, postoperative progress notes, consultation records, and expert diagnostic evaluations.

Time frame: Within 30 days after surgery.