Prognostic Impact of Frailty in Cardiogenic Shock

Samsung Medical Center207,419 enrolled

Overview

The goal of this observational study is to show prognostic impact of frailty in cardiogenic shock according to age. The main questions it aims to answer are: * Can frailty successfully predict outcomes in cardiogenic shock? * Whether the impact of frailty would differ with age in cardiogenic shock?

Study Type

OBSERVATIONAL

Enrollment

207,419

Conditions

Cardiogenic Shock Frailty Age

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults aged ≥18 years who were admitted to the intensive care unit (ICU) of tertiary hospitals and were diagnosed with CS Exclusion Criteria: * Patients diagnosed with anaphylaxis * Patients with a documented history of shock in the year before the index admission

Outcomes

Primary Outcomes

In-hospital all-cause mortality

Death from any cause occurring during the index hospitalization for cardiogenic shock. Number of participants with the event was measured

Time frame: During index hospitalization for cardiogenic shock (up to hospital discharge)

Secondary Outcomes

Heart failure-related rehospitalization

Any inpatient admission with a primary or secondary diagnosis of heart failure (ICD-10 I50.x), identified from claims data and prescription records.Number of participants with the event was measured.

Time frame: From index hospitalization until 15 years of follow-up.

Cognitive impairment

New-onset cognitive dysfunction after discharge, defined using ICD-10 codes (R41.x for memory disturbance, F06.7 for mild cognitive disorder) or new diagnosis of dementia (F00-F03, G30) or prescription of anti-dementia medications (donepezil, rivastigmine, galantamine, memantine). Number of participants with event was measured

Time frame: From index hospitalization until 15 years of follow-up.

Mental health problems

Composite of new-onset psychiatric diagnoses after discharge including 6 domains defined using ICD-10 codes. Domains include depression (ICD-10 F32-F33), anxiety disorders (F41.x), somatization disorder (F45.x), stress-related disorders (F43.x), sleep disorders (G47.x), and substance use disorders (F10-F19). Diagnostic codes supported by prescription data (e.g., antidepressants, anxiolytics). Number of participants with the event was measured.

Time frame: From index hospitalization until 15 years of follow-up.

Long-term all-cause mortality

Death from any cause, identified with the Statistics Korea nationwide death registry. Number of participants with the event was measured.

Time frame: From index hospitalization until 15 years of follow-up.

Data from ClinicalTrials.gov

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