Comparative Effect of High-Level Versus Low-Level Laser Therapy on Nerve Root Function Among Healthy Young Adults: A Randomized Controlled Trial

Overview

Study title: Comparative Effect of High-Level Versus Low-Level Laser Therapy on Nerve Root Function Among Healthy Young Adults: A Randomized Controlled Trial You are invited to participate in a research study to investigate the short-term effect of high-intensity laser therapy (HILT), low-level laser therapy (LLLT), and sham laser on nerve root function among healthy adults. Participation is entirely voluntary, and you may withdraw from the study at any time without penalty or need for justifications if you choose to do so. What is the aim of the study? The objective of the current study is to investigate the short-term effect of high-intensity laser therapy (HILT), low-level laser therapy (LLLT), and sham laser on nerve root function among healthy adults. Type of participants? We are recruiting participants aged 18-30 years of both genders without any musculoskeletal or neurological disorder involving the upper extremities, non-smokers, and if they expressed their wellness to participate in the current study. What will participants be asked to do? The purpose of this study is to investigate the short-term effect of high-intensity laser therapy, low-level laser therapy, and sham laser on nerve root function among healthy adults. If you agree to take part: * First, we will check if you are eligible for the study. * If you are eligible and give your consent, you will be randomly placed into one of three groups: 1. High-intensity laser therapy group 2. Low-level laser therapy group 3. Sham (placebo) group - in this group, the laser device will look and feel the same, but it will not actually deliver laser treatment. * If you are in the sham group, you will not receive active laser therapy. This is important for the scientific accuracy of the study, as it allows us to compare the effects of real laser therapy with no treatment. You will not know which group you are in during the study, but you will be informed after your participation is complete. * You will attend 9 short sessions over 3 weeks (3 sessions per week). Each session will last about 5-10 minutes. * To measure nerve function before laser application (Step 1): 1. A small gel will be used to place two sensors on your head (these can be removed easily). 2. Three nerves in your arm will be tested using very light, safe electrical pulses delivered through a small hand-held electrode held in place with a strap. 3. This helps us measure how your nerves are working before laser treatment by measuring the peak-to-peak amplitude and latency of N20 point of the brain through analyzing the brain waves. * Laser or sham application (Step 2): 1. A researcher will apply the laser (or sham) to three spots on your neck. 2. Each spot will receive laser for about 2 minutes. 3. The laser used is safe, does not cause heat, and you will not feel any burning. * Measuring nerve function again (Step 3): The same nerve test from step 1 will be repeated to see if there are any changes after the laser application. * Men do not need to remove any clothing. * Women who wear a headscarf will be asked to temporarily remove it so the head sensors can be placed. This will be done in a private room by a female researcher only, with doors locked and separators used to ensure complete privacy. * Male participants will also be attended to by a male researcher in the same respectful and private way. * It is very important to note that you may be assigned to a group where the laser is not actually turned on (sham group). This is important for the scientific accuracy of the study. * You will be told which group you were in after the study is completed.