This research aim is to investigate the correlation between triglyceride glucose index (TyG index) and myocardial infarct size, microcirculation obstruction (MVO) and intramyocardial hemorrhage (IMH) assessed by cardiac magnetic resonance imaging (CMR) in patients with ST-segment elevation myocardial infarction (STEMI), and to evaluate its value as a potential predictor of myocardial injury.To further determine the influence of TyG index on the prognosis of STEMI patients after PCI.This cohort included 674 patients with STEMI undergoing primary percutaneous coronary intervention (pPCI). Baseline clinical data were collected and cardiac magnetic resonance imaging was performed approximately 7 days after Acute Myocardial Infarction(AMI). Patients were divided into three groups according to the TyG index , namely high TyG index group, medium TyG index group and low TyG index group. Multiple linear regression, Pearson/Spearman correlation analysis and Logistics regression analysis were used to analyze the correlation between TyG index and myocardial infarct size, microcirculation obstruction and intramyocardial hemorrhage.Eventually, we came to the conclusion that the TyG index was independently associated with severity of myocardial injury after STEMI as assessed by CMR. TyG index is not only an independent predictor of microcirculation disturbance in STEMI patients, but also significantly correlated with poor cardiovascular prognosis. is a powerful marker for stratifying risk of adverse cardiovascular events.
Study Type
OBSERVATIONAL
Enrollment
674
Chinese PLA General Hospital
Beijing, Beijing Municipality, China
major adverse cardiovascular events
Death , recurrence of myocardial infarction, heart failure after discharge
Time frame: 4 years after discharge
myocardial infarct size
LGE sequences are acquired from CMR .The LGE images were analyzed manually or semi-automatically with software tools to calculate the size or volume of the infarct area .
Time frame: Cardiac MRI within 7 days after surgery
Microvascular occlusion
T1-weighted sequences are acquired from CMR and analyzed by software.Identified by early or late gadolinium-enhanced imaging using T1-weighted sequences with high inversion times
Time frame: Cardiac MRI within 7 days after surgery
Intramyocardial hemorrhage (IMH)
IMH was detected by T2-weighted imaging or T2 mapping, identified using low signal areas.
Time frame: Cardiac MRI within 7 days after surgery
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