Composite Ratios Boost CRP's Power in Monitoring Ulcerative Colitis.

Benha University80 enrolled

Overview

Inflammatory Bowel Disease (IBD) is a chronic, recurrent condition marked by disturbed levels of various hematological inflammatory cells and a deregulated immune environment. While C-reactive protein (CRP) is a key acute-phase reactant, its high levels can persist even after inflammation subsides. Other simple, cost-effective ratios, such as the Neutrophil-to-Lymphocyte Ratio (NLR), the Platelet-to-Lymphocyte Ratio (PLR), and Albumin-related ratios, also serve as promising, reproducible markers of systemic inflammation reflecting both immune status and nutrition. This study's objective is to evaluate the diagnostic performance of these various hematological inflammatory cellular components and CRP-related ratios (like the CAR) as predictors for Ulcerative Colitis (UC) disease severity, using colonoscopic and microscopic findings as the gold standard for comparison.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Ulcerative Colitis

Interventions

C-Reactive Protein measuring CRPDIAGNOSTIC_TEST

5-ml peripheral blood samples were aseptically obtained for a complete blood count, and ELISA estimation of serum CRP

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who fulfilled the diagnostic criteria for UC; * Patients were free of exclusion criteria; * Patients who signed the written consent were enrolled in the study Exclusion Criteria: * Patients who was Previously diagnosed with IBD or IBS; * Patients with recurrence of manifestations after surgical resection; * Patients who refused to sign the participation consent.

Outcomes

Primary Outcomes

The Correlation Between Clinical and Endoscopic Diagnostic Indices and Hematologic Ratios

Evaluating the role of diagnostic indices (Ulcerative Colitis Disease Activity Index (UC-DAI), Simple Clinical Colitis Activity Index (SCCAI), Fecal Calprotectin (FCP) ≥150μg/ml) in active Ulcerative Colitis (UC) and their correlation with novel hematologic inflammatory markers, including Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Systemic Inflammatory Response Index (SIRI), Systemic Inflammation Index (SII), and the serum C-Reactive Protein (CRP)-to-Albumin Ratio (CAR).

Time frame: 45 days