Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America

ICU mortality

The variable is coded as 1 = deceased and 0 = alive by the time of ICU discharge

Time frame: From enrollment to ICU discharge or 90 days (whichever occurs first)

90-day follow-up mortality

The variable is coded as 1 = deceased and 0 = alive by the time of 90-day follow-up

Time frame: From enrollment to 90-days post-ICU admission follow-up

Length of stay in the ICU

Length of stay will be calculated as the total number of full days between admission and discharge from the ICU. A calendar day will be counted toward the total only if the duration of stay on that day is two hours or longer.

Time frame: From ICU admission to death or ICU discharge (truncated at 90 days)

Length of stay in the hospital

Length of stay will be calculated as the total number of full days between admission and discharge from the hospital. A calendar day will be counted toward the total only if the duration of stay on that day is two hours or longer.

Time frame: From hospital admission to death or hospital discharge (truncated at 90 days)

Renal function recovery at hospital discharge

Recovery will be defined as improvement in kidney function based on serum creatinine value at hospital discharge compared with baseline serum creatinine. Baseline serum creatinine will be defined as either of the following (in order of priority) 1) Average of 3 closest outpatient values 7-365 days before index hospitalization; 2) Lowest value in the inpatient setting 7-365 days before index hospitalization; 3) Lowest value in the first 30 days during index hospitalization (not during or within 48h after RRT discontinuation). Patients who have serum creatinine \<0.3 mg/dL higher than baseline at hospital discharge will be considered to have recovered renal function.

Time frame: From enrollment to hospital discharge or 90 days (whichever occurs first)

Renal function recovery at follow-up

Recovery will be defined as improvement in kidney function based of serum creatinine value at follow-up compared with baseline serum creatinine. Baseline serum creatinine will be defined as either of the following (in order to priority) 1) Average of 3 closest outpatient values 7-365 days before index hospitalization; 2) Lowest value in the inpatient setting 7-365 days before index hospitalization; 3) Lowest value in the first 30 days during index hospitalization (not during or within 48h after RRT discontinuation). Patients who have serum creatinine \<0.3 mg/dl higher than baseline at follow-up will be considered to have recovered renal function.

Time frame: From enrollment to 90-days post-ICU admission follow-up

RRT dependence at hospital discharge

Patients will be classified as RRT-dependent if they continue to require any form of RRT at discharge. Patients who no longer require RRT will be classified as RRT-independent.

Time frame: From RRT initiation to hospital discharge or 90 days (whichever occurs first)

RRT dependence at follow-up

Patients will be classified as RRT-dependent if they continue to require any form of RRT at follow-up assessment. Patients who no longer require RRT will be considered RRT-independent.

Time frame: From RRT initiation (day 0) to 90-days post-ICU admission follow-up

Anticoagulation-related complications associated with RRT

These include complications attributable to different types of anticoagulation (systemic unfractionated heparin, systemic low molecular weight heparin, regional citrate anticoagulation, other) used during RRT. Events include hemorrhage, heparin-induced thrombocytopenia (where relevant), citrate excess (where relevant), and citrate deficit (where relevant).

Time frame: RRT initiation (day 0) to RRT day 6 or RRT termination (whichever occurs first)

Infectious complications associated with RRT

These include infections associated with RRT. Events include catheter-related bloodstream infections, catheter insertion-site infections, and secondary peritonitis.

Time frame: RRT initiation (day 0) to RRT day 6 or RRT termination (whichever occurs first)

RRT-related procedural complications

Procedural or mechanical complications occurring during RRT will be identified from medical records and bedside documentation. These include catheter malfunction (e.g., kinking, disconnection, malposition, migration, catheter tip adherence to vessel wall), circuit interruptions, circuit replacements, RRT downtime (where relevant).

Time frame: RRT initiation (day 0) to RRT day 6 or RRT termination (whichever occurs first)