This study aims to comprehensively identify the various treatment patterns of second- or subsequent-line palliative chemotherapy used in patients with metastatic colorectal cancer who have experienced failure of first-line palliative chemotherapy and to evaluate the prognosis of each treatment.
Study Type
OBSERVATIONAL
Enrollment
1,000
As this is a non-interventional study designed to collect data as part of routine clinical practice, the selection and dosage of medication, treatment period, and whether or not to change it are all based on the clinician's judgment
Samsung Medical Center
Seoul, South Korea
RECRUITINGProgression-free survival (PFS)
Progression-free survival (PFS) by treatment pattern
Time frame: up to 24 months
Overall Survival (OS)
Overall Survival (OS) by treatment pattern
Time frame: up to 24 months
Dosage period for each treatment pattern
Time frame: up to 24 months
Objective Response Rate (ORR)
Time frame: up to 24 months
Types of Secondary palliative chemotherapy
Time frame: up to 24 months
Types of Third palliative chemotherapy
Time frame: up to 24 months
Conversion rate
Conversion rate to resectable group by treatment pattern
Time frame: up to 24 months
Quality of Life Assessment
The FACT-C (Functional Assessment of Cancer Therapy-Colorectal) questionnaire uses a 5-point Likert-type scale. The responses generally range from 0 (Not at all) to 4 (Very much).
Time frame: up to 12 months
Eastern Cooperative Oncology Group Performance Status(ECOG PS) Assessment
The ECOG PS uses a scale from 0 to 5, where a score of 5 specifically means the patient is deceased. The score of 0 indicates the best performance status (fully active), while 4 indicates the worst performance status for a living patient (completely disabled/bedridden).
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Time frame: up to 24 months