A Study of HS-10518 in Healthy Adult Premenopausal Females in China

Inclusion Criteria: * Subjects may be enrolled only if they meet all the following criteria: 1. At the time of signing the informed consent form, the subject must be 18 to 40 years old (inclusive). 2. Confirmed to be a healthy subject through medical assessment, including indicators such as medical history, physical examination, laboratory tests, and 12-lead electrocardiogram (ECG). 3. Regular menstrual cycles for at least 6 months prior to screening, with: * Cycle length: 24 to 32 days; * Menstrual period duration: 2 to 7 days;(The first day of menstruation is defined as Day 1 of the menstrual cycle.) 4. Baseline sex hormone levels meet the following requirements: Follicle-Stimulating Hormone (FSH) \< 10 IU/L and Estradiol (E2) \< 100 pg/mL; in addition, other sex hormone indicators must be assessed by the investigator as normal for the subject to be randomly enrolled. 5. Body weight ≥ 45 kg, and Body Mass Index (BMI) within the range of 18 to 28 kg/m² (inclusive). 6. The subject agrees to use highly effective non-hormonal contraceptive methods from the date of signing the informed consent form until 3 months after the administration of the last dose of the study drug. Highly effective non-hormonal contraceptive methods include: * Continuous abstinence; * Surgical sterilization of the subject (performed at least 3 months prior to signing the informed consent form); * Surgical sterilization of the subject's sexual partner (performed at least 6 months prior to signing the informed consent form).Other dual non-hormonal contraceptive methods are also acceptable, including: * Condoms with spermicides; * Diaphragms with spermicides (used with or without condoms); * Cervical caps with spermicides (used with or without condoms); * Vaginal sponges with spermicides (used together with condoms). 7. Have a full understanding of the study content, process, and potential adverse reactions, and voluntarily sign the informed consent form. Exclusion Criteria: * Subjects will be excluded from the study if they meet any one of the following criteria: 1. Has a history of abnormal uterine bleeding within 3 months prior to screening. 2. Has never been sexually active. 3. Has consumed foods or beverages rich in caffeine and/or xanthine (e.g., coffee, tea, chocolate, caffeinated carbonated beverages such as cola), tobacco-containing products (e.g., cigarettes), alcohol, or alcohol-containing products within 48 hours prior to drug administration. 4. Has consumed grapefruit, grapefruit juice, bitter orange, bitter orange marmalade, bitter orange juice, or other products containing grapefruit or bitter orange within 7 days prior to the first dose. 5. Has a history of smoking or alcohol abuse within 6 months prior to screening: * Smoking: More than 5 cigarettes per day or equivalent tobacco products; * Alcohol abuse: Alcohol consumption of ≥14 units per week (1 unit = 285 mL of beer, 25 mL of spirits with alcohol content ≥40%, or 150 mL of wine). 6. Is suspected of substance abuse involving barbiturates, amphetamines, benzodiazepines, cocaine, opioids, cannabis, methadone, phencyclidine (PCP), tricyclic antidepressants (TCAs), or methamphetamine. 7. Has a positive alcohol breath test or positive urine drug abuse screening result. 8. Is pregnant, lactating, or has a positive serum beta-human chorionic gonadotropin (β-hCG) test at screening. 9. Has a history of malignant tumors (cancer). 10. Has had clinically significant gastrointestinal complaints, a history of gastrointestinal diseases (e.g., Crohn's disease, ulcerative colitis), or a history of surgery that may affect the absorption of the study drug (except for simple appendectomy or hernia repair) within 7 days prior to the first dose. 11. Has a history of migraine, epilepsy, convulsions, depression, or a clinically significant depressive state. 12. Has a history of thyroid or parathyroid dysfunction, or has thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), or free thyroxine (FT4) levels outside the normal reference range-except if the investigator determines that the abnormality does not affect the study. 13. Is within 6 months after childbirth, abortion, or cessation of lactation. 14. Has a history of severe drug hypersensitivity, allergic diseases (e.g., asthma, urticaria, allergic rhinitis), or a history of atopy (allergic to ≥2 allergens)-if the investigator determines that the subject is unsuitable for the study. 15. Has donated blood, lost ≥400 mL of blood, or received a blood transfusion within 3 months prior to screening; or has donated blood or lost ≥200 mL of blood within 1 month prior to screening. 16. Has used any medications (prescription drugs, over-the-counter (OTC) drugs, traditional Chinese medicines, dietary supplements including vitamins, etc.) or short-term topical medications within 4 weeks prior to the first dose (or at least 5 times the respective elimination half-life, whichever is longer)-except if the investigator determines that the use does not affect the study. 17. Has positive results for hepatitis B surface antigen (HBsAg), hepatitis C antibody (anti-HCV), human immunodeficiency virus antibody (anti-HIV), or syphilis serological test (TRUST)/treponema pallidum antibody (TP-Ab) at screening-except for subjects judged by the investigator to have a history of syphilis but have been cured. 18. Has alanine transaminase (ALT) or aspartate transaminase (AST) levels exceeding the upper limit of normal (ULN) at screening. 19. Has serum creatinine \> 1.5 × ULN, or an estimated glomerular filtration rate (eGFR) \< 60 mL/min/1.73 m² (calculated using the Modification of Diet in Renal Disease (MDRD) formula) at screening. 20. Has abnormal and clinically significant electrocardiogram (ECG) findings at screening (e.g., absolute value of QTcF \[QT interval corrected by Fridericia's formula: QT/RR⁰·³³\] \> 470 milliseconds \[ms\]). 21. Has diseases related to the ovaries, breasts, uterus, hypothalamus, or pituitary gland-if the investigator determines that the subject is unsuitable for the study. 22. Has sonographic evidence of physiological abnormalities in the uterus and bilateral ovaries-if the investigator determines that the subject is unsuitable for the study. 23. Has abnormal and clinically significant results from a cervical ThinPrep cytology test (TCT) during screening or within the past 12 months; for subjects with TCT results of "atypical squamous cells of undetermined significance (ASC-US)", enrollment is permitted only if high-risk human papillomavirus (HPV) testing is negative. 24. Has recently used prohibited medications: * Used short-acting preparations containing sex hormones or affecting sex hormone levels (oral, transdermal, intravaginal, etc.) within 3 months prior to the first dose; * Used long-acting preparations containing sex hormones or affecting sex hormone levels (any long-acting injections or implants) within 6 months prior to the first dose. 25. Plans to become pregnant during the study or within 3 months after the study ends. 26. Participated in other clinical drug trials within 3 months prior to screening. 27. Has other conditions or reasons deemed by the investigator to make the subject unsuitable for participation in the clinical study.