The purpose of this study is to evaluate how well JNJ-79635322 works (efficacy) in participants with Relapsed or Refractory Multiple Myeloma (RRMM; a cancer that forms in a type of white blood cells called a plasma cell. Cancer is called relapsed if it comes back after treatment and is called 'refractory' if does not respond to treatment) who have received at least 3 prior lines of therapy.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
157
JNJ-79635322 will be administered as an injection under the skin.
Ha'Emek Medical Center
Afula, Israel
RECRUITINGSamson Assuta Ashdod University Hospital
Ashdod, Israel
RECRUITINGHillel Yaffe Medical Center
Hadera, Israel
Overall Response Rate (ORR)
Time frame: Up to 2 years and 9 months
Very Good Partial Response (VGPR) or Better Rate
Time frame: Up to 2 years and 9 months
Complete Response (CR) or Better Rate
Time frame: Up to 2 years and 9 months
Duration of Response (DoR)
Time frame: Up to 2 years and 9 months
Progression-Free Survival (PFS)
Time frame: Up to 2 years and 9 months
Overall Survival (OS)
Time frame: Up to 2 years and 9 months
Time To Next Line of Therapy (TTNT)
Time frame: Up to 2 years and 9 months
Number of Participants With Treatment-Emergent Adverse Event (TEAE) by Severity
Time frame: Up to 2 years and 9 months
Change from Baseline in Symptoms, Functioning, and Health-related Quality of Life (HRQoL) as Assessed by Multiple Myeloma Symptom and Impact Questionnaire (MySIm-Q) Scale Score
Time frame: From Baseline up to 2 years and 9 months
Change from Baseline in Symptoms, Functioning, and HRQoL as Assessed by European Organization for Research and Treatment of Cancer Quality of life Questionnaire Core 30 (EORTC-QLQ-C30) Scale Score
Time frame: From Baseline up to 2 years and 9 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Hadassah Medical Center
Jerusalem, Israel
RECRUITINGRabin Medical Center
Petah Tikva, Israel
RECRUITINGTel Aviv Sourasky Medical Center
Tel Aviv, Israel
RECRUITINGChange from Baseline in Symptoms, Functioning, and HRQoL as Assessed by European Quality of Life 5-Dimensions 5-Level Version (EQ-5D-5L) Scale Score
Time frame: From Baseline up to 2 years and 9 months
Time to Worsening in Symptoms, Functioning, and HRQoL as Assessed by MySIm-Q
Time frame: Up to 2 years and 9 months
Time to Worsening in Symptoms, Functioning, and HRQoL as Assessed by EORTC-QLQ-C30
Time frame: Up to 2 years and 9 months
Time to Worsening in Symptoms, Functioning, and HRQoL as Assessed by EQ-5D-5L
Time frame: Up to 2 years and 9 months
Percentage of Participants With Meaningful Improvement in Symptoms, Functioning, and HRQoL as Assessed by MySIm-Q
Time frame: Up to 2 years and 9 months
Percentage of Participants With Meaningful Improvement in Symptoms, Functioning, and HRQoL as Assessed by EORTC-QLQ-C30
Time frame: Up to 2 years and 9 months
Percentage of Participants With Meaningful Improvement in Symptoms, Functioning, and HRQoL as Assessed by EQ-5D-5L
Time frame: Up to 2 years and 9 months
Serum Concentrations for JNJ-79635322
Time frame: Up to 2 years and 9 months
Number of Participants With Anti JNJ-79635322 Antibodies
Time frame: Up to 2 years and 9 months
Number of Participants With JNJ-79635322 Neutralizing Antibodies (NAb)
Time frame: Up to 2 years and 9 months