Gabapentin and Diclofenac Sodium Comparison for Post-Operative Pain Relief

Muhammad Aamir Latif240 enrolled

Overview

Little is known about comparative efficacy of gabapentin and diclofenac sodium in managing post-operative pain. Therefore, this study was planned to compare the efficacy of gabapentin, and diclofenac sodium for post-operative pain relief in patients undergoing major abdominal surgeries.

Non-steroidal anti-inflammatory drugs, opioid analgesics, and local and regional anesthesia have been used as preventive interventions, but their role in postoperative pain management remains inconclusive. Gabapentin is a relatively new drug for postoperative pain management whose side effects are well tolerated. If the findings of this study produce similar observations, it would add to the already scarce data and help patients undergoing major abdominal surgeries in the local settings in relieving postoperative pain effectively.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

240

Conditions

Postoperative Pain

Interventions

Gabapentin 600mgDRUG

Patients received a single oral dose of gabapentin 600 mg one hour before surgery.

Diclofenac Sodium 100 MGDRUG

Patients were given a single oral dose of diclofenac sodium 100 mg one hour before surgery.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Any gender * Aged 18-60 years * Undergoing elective major abdominal surgery under general anesthesia * With physical status I or II * Who were able to comprehend and use the Visual Analogue Scale (VAS) for pain assessment Exclusion Criteria: * With a known allergy or contraindication to gabapentin, or diclofenac sodium * A history of peptic ulcer disease * A history of gastrointestinal bleeding * Hepatic or renal dysfunction * Pregnancy or lactation * With neurological or psychiatric disorders affecting pain perception * Received opioids, anticonvulsants, antidepressants, or nonsteroidal anti-inflammatory drugs (NSAIDs) within 24 hours before surgery * With uncontrolled hypertension, ischemic heart disease, or diabetes mellitus * Those who experienced intraoperative complications necessitating a change in anesthetic plan or postoperative mechanical ventilation

Locations (1)

Bahawal Victoria Hospital

Bahawalpur, Punjab Province, Pakistan

Outcomes

Primary Outcomes

Pain reduction

Patients were considered to have effective pain relief ("Yes") if their VAS score remained ≤3 throughout the monitoring period without requiring rescue analgesia.

Time frame: 12 hours

Data from ClinicalTrials.gov

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