Intravenous Atropine in Reducing Reperfusion Arrhythmias, Conduction Abnormalities and Hypotension in Inferior ST-elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Phase 4RecruitingNCT07268586

Ain Shams University150 enrolled

Overview

People with acute inferior wall myocardial infarction will be given an intravenous drug called atropine that increases the heart rate to check if it prevents heart rhythm disturbances during performing coronary intervention

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

150

Conditions

Myocardial Infarction

Interventions

Intravenous atropine immediately before wire crossing during primary percutaneous coronary interventionDRUG

Intravenous atropine 1 mg immediately before wire crossing during primary percutaneous coronary intervention

Intravenous normal saline as placebo immediately before wire crossing during primary percutaneous coronary interventionDRUG

Intravenous normal saline as placebo immediately before wire crossing during primary percutaneous coronary intervention

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Acute inferior ST elevation myocardial infarction Exclusion Criteria: * Execution of rescur percutaneous coronary intervention after thrombolysis * Mechanical complications or no reflow or spontaneous reperfusion. * Prior implantation of permanent or temporary pacemakers * History of bradycardia, hypotension or ventricular tachycardia with a definitive cause (unrelated to the disease under study) * Prior coronary artery bypass graft surgery * Atropine contraindications Unwillingness to participate in the

Locations (1)

Ain Shams University

Cairo, Abbasia, Egypt

RECRUITING

Outcomes

Primary Outcomes

Conduction abnormalities

Occurrence of conduction abnormalities

Time frame: Periprocedurally

Reperfusion arrhythmias

Occurrence of reperfusion arrhythmias

Time frame: Periprocedurally

Secondary Outcomes

Major adverse cardiac events

Inhospital major adverse cardiac events including all-cause mortality, cardiovascular mortality, stroke and myocardial infarction

Time frame: Periprocedurally

Central Contacts

Mohamed G Elewa, MD

CONTACT

+201019811895 mdgamal92@gmail.com

Data from ClinicalTrials.gov

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