Moderate-to-Severe Dry Eye Disease Relief Using Acoltremon

Inclusion Criteria: * Adults aged 18 years or older with clinical diagnosis of DED within past 6 months * Use or desire for artificial tears for DED symptoms within past 2 months * OSDI score \>25 and \<50 at Screening * TBUT \<10 seconds * Baseline tCFS score ≥2 and ≤15 (modified NEI) Exclusion Criteria: * History of corneal or conjunctival surgery * History of herpes zoster ophthalmicus, herpes simplex virus keratitis, or other viral corneal infection * History of neurotrophic keratitis * Prior significant facial trauma or sinus surgery * Mental or physical condition impairing ability to complete questionnaires * Use of Restasis®, Xiidra®, or Miebo within 30 days * Use of other topical anti-inflammatory medications within 30 days * Use of varenicline nasal spray within 30 days * Use of artificial tears within 2 hours prior to screening or during study period * Glaucoma requiring topical therapy * Contact lens or eyelid scrub use within 7 days * Punctal plugs within 14 days * Oxervate historical use * Amniotic membrane or Serum Tears historical use * History of Sjögren's disease * History of LASIK within 1 year