Impact of dual trigger using recombinant human chorionic gonadotropin (HCG) and gonadotropin-releasing hormone (GnRH) agonist on thawed modified natural cycle outcomes: an open-label multi-center randomized controlled trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
170
GnRH agonist add to hcg for trigger
Implantation
Implantation is defined as a positive serum β-hCG (\>20 mIU/mL) measured 14 days after embryo transfer.
Time frame: 14 days after embryo transfer
Clinical pregnancy
Clinical pregnancy is defined as visualization of a gestational sac on transvaginal ultrasonography one week after pregnancy has been confirmed.
Time frame: one week after confirm pregnancy
Ongoing pregnancy rate
An ongoing pregnancy is defined as a viable intrauterine pregnancy with fetal cardiac activity at ≥9 weeks' gestational age.
Time frame: 5 weeks after confirmed pregnancy
Miscarriage rate
Time frame: before delivery
Gestational age (weeks) at delivery
Gestational age (weeks) at delivery
Time frame: delivery
Live birth rate
Time frame: delivery
Birth weight
Birth weight of the bewborn (kg)
Time frame: delivery
Presence of significant congenital or medical conditions of the newborn
Presence of significant congenital or medical conditions of the newborn
Time frame: delivery
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