To evaluate the blood pressure lowering effects of thiazide diuretics in patients on peritoneal dialysis
This prospective, single-center treatment-withdrawal crossover study enrolled 10 patients on chronic peritoneal dialysis (PD) and uncontrolled hypertension (SBP \>140 mmHg and/or DBP \>90 mmHg). Following written informed consent, participants entered the treatment arm, receiving oral hydrochlorothiazide once daily on top of their standard of treatment for 90 days. This was followed by a 14-day washout period, after which participants entered a 90-day control period.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Thiazides diuretics
Prince of Wales Hospital. The Chinese University of Hong Kong
Hong Kong, Hong Kong
RECRUITINGChange in systolic and diastolic blood pressure
Time frame: 90 days
Changes in body weight
Time frame: 90 days
Changes in body composition measured by bio impedance spectroscopy
Time frame: 90 days
Change in urinary fractional excretion of sodium
Time frame: 90 days
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