Research on Anesthesia Depth Control Strategy Based on Continuous and Non-invasive Monitoring of Exhaled Breath

N/ARecruitingNCT07272044

Second Affiliated Hospital, School of Medicine, Zhejiang University500 enrolled

Overview

This study aims to propose a strategy for controlling the depth of anesthesia based on continuous and non-invasive monitoring of exhaled breath: BIS value during intravenous-inhalation combined anesthesia is predicted according to the real-time exhaled concentrations of sevoflurane and propofol, so as to achieve the depth of anesthesia management for patients who cannot use standard BIS. Furthermore, the relationship between anesthetic concentration and depth of anesthesia was analyzed in different subgroups.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Anesthesia

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥18 years old * ASA I-III * Expected duration of surgery \> 1 hour * Radial artery catheterization was performed * Patients requiring BIS monitoring. Exclusion Criteria: * Patients with contraindications to general anesthesia * mental disorder, unable to answer * long-term use of antiepileptic drugs and psychotropic drugs * pregnant patients * patients refused to participate * the investigator thought that the study was not suitable for inclusion * patients who did not wake up in PACU

Locations (1)

Second Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, China

Outcomes

Primary Outcomes

Correlation and consistency analysis between exhaled breath concentrations of two anesthetics and BIS values

Correlation and consistency analysis between exhaled breath concentrations of two anesthetics detected by GC-SAW system and BIS values

Time frame: 1 day

Establish a 3D drug dose-effect model of the exhaled concentration and BIS value of anesthetics

Establish a 3D drug dose-effect model based on the exhaled gas concentration of anesthetics detected by the GC-SAW system and BIS value

Time frame: 1day

Secondary Outcomes

Correlation and consistency analysis of exhaled breath concentration and blood concentration of anesthetics

Correlation and consistency analysis of exhaled breath concentration and blood concentration of anesthetics detected by GC-SAW system

Time frame: 1day

The incidence of adverse reactions

The occurrence of adverse reactions such as postoperative cognitive dysfunction, postoperative nausea and vomiting, chills, and delayed awakening within 72 hours after the operation

Time frame: 72 hours