Time-restricted eating - where no food is consumed over a period of time - has been shown to promote weight loss and improve cardio-metabolic function. In individuals with type 2 diabetes, it is also been shown to improve glucose control. The investigators propose a randomized controlled trial to determine whether time-restricted eating is an effective therapeutic strategy that can preserve pancreatic beta-cell function and improve glycemic control early in participants with type 2 diabetes.
In this study, eligible patients with type 2 diabetes will be randomized to either time-restricted eating or standard lifestyle. The hypothesis under study is whether time-restricted eating can improve pancreatic beta-cell function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
112
18 hours of fasting and 6 hour window of eating (between 2 to 8 PM) every day for 52 weeks.
standard lifestyle recommendations as per Diabetes Canada guidelines \[where patients are encouraged to maintain regularity in timing and spacing of meals with no specific recommendation regarding hours of fasting\]
Leadership Sinai Centre for Diabetes
Toronto, Ontario, Canada
RECRUITINGDifferences in baseline-adjusted Insulin-Secretion-Sensitivity Index-2 (ISSI-2) between the study groups.
Baseline-adjusted beta-cell function at 52 weeks, measured by Insulin Secretion-Sensitivity Index-2 (ISSI-2).
Time frame: 52-weeks
Differences in baseline-adjusted insulin resistance between the study groups
Baseline-adjusted insulin resistance at 52-weeks measured by HOMA-IR
Time frame: 52-weeks
Differences in time in glucose target range between each study group
Time in glucose target range indicates the amount of time (in %) that glucose readings are within the defined target glucose range of 3.9-10.0 mmol/L.
Time frame: 52-weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.