A prospective cluster-randomized quality improvement trial was conducted to evaluate whether a structured nurse education program on ventilator waveform interpretation and alarm management reduces patient-ventilator asynchrony in the pediatric intensive care unit. Two PICU units within the same hospital were randomized to either an Education group or a Control group. Nurses in the Education group received multimodal training, reference cards, and support for real-time waveform review. The primary outcomes were asynchrony index (%) and ventilator alarm frequency (alarms/day). Secondary outcomes included ventilator days, cumulative sedation dose, withdrawal symptoms, nurse accuracy in identifying asynchrony, and nurse workload.
Patient-ventilator asynchrony (PVA) is common in mechanically ventilated children and is associated with impaired gas exchange, increased sedation exposure, prolonged mechanical ventilation, and higher morbidity. Recognition and management of asynchrony require real-time waveform interpretation, yet bedside nurses' ability to identify it varies widely. This prospective cluster-randomized quality improvement study was conducted in two pediatric intensive care units within the same tertiary children's hospital. The two PICUs were randomized 1:1 to either the Education group or the Control group. Children aged 1 month to 18 years who required at least 48 hours of invasive mechanical ventilation were eligible. In the Education group, bedside nurses participated in a structured, multimodal training program including face-to-face teaching, case-based waveform analysis, alarm management principles, and a mobile platform for sharing ventilator screenshots with an asynchrony review team. Reference pocket cards summarizing common asynchrony patterns and recommended responses were provided. Nurses performed routine waveform checks and communicated suspected asynchrony to the clinical team; ventilator settings were changed only by physicians. The Control group followed the existing standard of care without nurse-specific training. Asynchrony was quantified using 24-hour waveform recordings exported from the ventilator. Primary outcomes were asynchrony index (%) and total ventilator alarm frequency (alarms per ventilator day). Secondary outcomes included mechanical ventilation duration, cumulative sedation dose (mg/kg), withdrawal symptoms measured using the WAT-1 score, nurse accuracy before and after training, and nurse workload assessed using the NASA-TLX tool.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
64
A structured multimodal education program delivered to bedside nurses, including face-to-face teaching, case-based ventilator waveform interpretation, recognition of common patient-ventilator asynchrony patterns, ventilator alarm management principles, reference pocket cards, and real-time waveform sharing with an asynchrony review team. Nurses performed routine waveform checks and reported suspected asynchrony to physicians; ventilator adjustments were performed only by physicians.
Behcet Uz Children's Hospital - Pediatric Intensive Care Unit
Izmir, Turkey (Türkiye)
Asynchrony Index (%)
The proportion of asynchronous breaths divided by total breaths, expressed as a percentage. Asynchrony is quantified using 24-hour ventilator waveform recordings.
Time frame: Within the first 24 hours of invasive mechanical ventilation
Ventilator Alarm Frequency (alarms/day)
The total number of ventilator alarms per ventilator day, including pressure, volume, and flow-related alarms.
Time frame: Within the first 24 hours of invasive mechanical ventilation
Duration of Mechanical Ventilation (days)
Number of days from initiation of invasive mechanical ventilation to successful extubation or transition to noninvasive ventilation.
Time frame: Up to 28 days or until discontinuation of invasive mechanical ventilation, whichever comes first.
Cumulative Sedation Dose (mg/kg)
Total cumulative dose of sedative medications administered during mechanical ventilation, normalized to patient weight.
Time frame: Up to 28 days or until discontinuation of invasive mechanical ventilation, whichever comes first.
Nurse Accuracy in Identifying Asynchrony (%)
Proportion of correctly identified asynchrony patterns on pre-training and post-training waveform tests.
Time frame: Within the first 24 hours of invasive mechanical ventilation
Withdrawal Severity (WAT-1 Score)
Maximum Withdrawal Assessment Tool-1 (WAT-1) score recorded during mechanical ventilation and weaning.
Time frame: Up to 48 hours after extubation following a period of mechanical ventilation.
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