Stellate Ganglion Block on Postoperative Sleep Status in Patients With Prolonged Disorders of Consciousness

N/ANot Yet RecruitingNCT07274683

Beijing Tiantan Hospital25 enrolled

Overview

The goal of this clinical trial is to learn about the effect of preoperative administration of stellate ganglion block on postoperative sleep status in patients with prolonged disorders of consciousness. The main aims to answer are: • To explore the effect of preoperative administration of stellate ganglion block on postoperative polysomnography and total sleep time in patients with prolonged disorders of consciousness. • To explore the effect of preoperative administration of stellate ganglion block on postoperative cerebral oxygen saturation, cerebral hemodynamic parameters and recovery of consciousness. Participants will be pDoC patients with intact skulls after acquired brain injury who will undergo spinal cord electronic stimulator implantation under general anesthesia at Beijing Tiantan Hospital. Stellate ganglion block will be administrated before the surgery. Polysomnography, total sleep time, cerebral oxygen saturation, cerebral hemodynamic parameters, CRS-R scores, GCS scores, WHIM scores and NCS scores will be investigated.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Stellate Ganglion Block Prolonged Disorders of Consciousness Sleep

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18-65 years; * Prolonged disorders of consciousness after acquired brain injury; * Scheduled to undergo spinal cord electronic stimulator implantation under general anesthesia; * The skull is intact; * Informed consent is obtained; Exclusion Criteria: * Continuous sedation therapy is performed within 72 hours prior to the study; * The integrity of brain structure is disrupted due to causes such as open head injury and cerebral parenchymal resection; * Decreased intracranial compliance caused by hydrocephalus and other reasons; * Airway stenosis or severe dysfunction of ventilation or gas exchange due to various causes; * Known or suspected severe cardiac, pulmonary, and renal dysfunction; * History of sedative drug allergy; * Complicated by other mental or neurological disorders; * Local anesthetic allergy; * Other reasons for ineligibility in this study; * Informed consent is not obtained;

Outcomes

Primary Outcomes

Total sleep time

total sleep time on PSG

Time frame: on the first postoperative night

Secondary Outcomes

cerebral oxygen saturation

Regional cerebral oxygen saturation (rSO₂) measured by near-infrared spectroscopy (NIRS).

Time frame: 30 minutes after stellate ganglion block

cerebral hemodynamic parameters

cerebral hemodynamic parameters measured by Transcranial Doppler（TCD）

Time frame: 30 minutes after stellate ganglion block.

the recovery of consciousness

Consciousness recovery will be assessed using the Coma Recovery Scale-Revised (CRS-R). It assesses patients across six functional domains: auditory, visual, motor, oromotor/verbal, communication, and arousal. The total score ranges from 0 to 23, with higher scores indicating a higher level of consciousness.

Time frame: 1 and 30 days postoperatively

Length of ICU stay

Time frame: 30 days postoperatively

Costs of ICU stay