Immunogenicity and Safety of 2 Doses of Avian Influenza A (H5N1) Vaccine Administered 3 vs. 8 Weeks Apart

Inclusion Criteria: 1. Individuals in stable health (defined as no new onset or exacerbation of pre-existing chronic disease three months prior to vaccination) 18-59 years of age. 2. Able to comply with the trial procedures. 3. Informed consent signed prior to trial-specific procedures. 4. If a person is at risk of becoming pregnant, has practiced adequate contraception for 28 days prior to visit 1, and has a negative pregnancy test on the day of vaccination and has agreed to continue adequate contraception until 60 days after the final vaccination. Risk of pregnancy is defined as any cis woman and/or gender divergent individual assigned female at birth or with reproductive capacity who is sexually active with individuals with sperm-producing capabilities. Individual who are post-menopausal or permanently sterile (hysterectomy, bilateral salpingectomy) are not considered at risk of pregnancy. A post-menopausal state is defined as a no menses for 12 months. Effective contraception methods are: * Combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation: * Oral * Intravaginal * Transdermal * Progestogen-only hormonal contraception associated with inhibition of ovulation: * Oral * Injectable * Implantable * Intra-uterine device (IUD) with or without hormonal release. * Vasectomised partner, provided that this partner is your sole sexual partner and that the vasectomised partner has received a medical assessment of the surgical success. * Credible self-reported history of heterosexual abstinence prior to and for at least 28 days after the vaccine. Effective contraception methods are: * Combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation: * Oral * Intravaginal * Transdermal * Progestogen-only hormonal contraception associated with inhibition of ovulation: * Oral * Injectable * Implantable * Intra-uterine device (IUD) with or without hormonal release. * Vasectomised partner, provided that this partner is your sole sexual partner and that the vasectomised partner has received a medical assessment of the surgical success. * Credible self-reported history of heterosexual abstinence prior to and for at least 28 days after the vaccine. Exclusion Criteria: * Any of the following: 1. Receipt of avian influenza A(H5N1) vaccine anytime. 2. Positive pregnancy test prior to vaccination, or breastfeeding. 3. Receipt of immunoglobulins and/or any blood products within 3 months preceding the first dose of study vaccine and for one month after the last dose of study vaccine (except Rho D). 4. Bleeding disorder or history of significant bleeding following IM injections or venipuncture. 5. Any confirmed or suspected immunosuppressive or immunodeficient state; asplenia, or immunosuppressant medication within the past 6 months except short term oral steroids (≤14 days duration) or topical steroids. 6. A significant acute disease or temperature ≥38 Co within 24 hours prior to vaccination (temporary exclusion criteria, participants can return for evaluation to be randomized/ vaccinated 72 hours after symptoms resolve). 7. Unstable chronic medical condition requiring ongoing follow-up and monitoring by a physician as determined by the investigator. 8. History of anaphylaxis or allergy to any of the constituents or trace residues of the study vaccine, including egg protein. 9. Receipt of non-study vaccine(s) 2 weeks prior to the study vaccine or planned 2 weeks after administration of the study vaccine.