Central Haemodynamics and Pacing for AV Block

University of Tartu124 enrolled

Overview

A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

124

Conditions

Atrioventricular Block Pacing Therapy Right Ventricular Pacing Conduction System Pacing

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-80 years * Diagnosis of atrioventricular block * Expected survival \>1 year Exclusion Criteria: * Reduced left ventricular ejection fraction (EF \<45%) * Expected ventricular pacing burden \<20% * Inter-arm systolic blood pressure difference \>15 mmHg * Percutaneous coronary intervention or coronary artery bypass surgery within the last 30 days * Secondary hypertension * Orthostatic hypotension * Clinically significant valvular heart disease * Congenital heart disease * Pulse wave analysis or pulse wave velocity measurement cannot be reliably performed * Pregnancy or breastfeeding * Withdrawal of consent by the subject * Loss of contact during the study

Locations (2)

North Estonia Medical Centre

Tallinn, Harju, Estonia

RECRUITING

Tartu University Hospital

Tartu, Tartu, Estonia

RECRUITING

Central Haemodynamics and Pacing for AV Block

Overview

Conditions

Interventions

Eligibility

Locations (2)

Outcomes

Primary Outcomes

Central Contacts