Use of Subanesthetic Dose Propofol Before Extubation

Yuzuncu Yil University80 enrolled

Overview

This study investigates whether administering a low, sub-anesthetic dose of propofol before extubation can reduce emergence agitation and improve perioperative comfort in patients undergoing rhinoplasty. Emergence agitation refers to restlessness and confusion during early recovery from anesthesia, which may affect patient safety and surgical conditions. The study evaluates agitation levels, recovery characteristics, and patient-reported comfort following propofol administration compared with standard care.

This study aims to evaluate whether administering a sub-anesthetic dose of propofol before extubation can reduce emergence agitation, enhance recovery characteristics, and improve patient comfort in adults undergoing rhinoplasty surgery. Emergence agitation is a common phenomenon during early recovery from general anesthesia and can involve restlessness, disorientation, and involuntary movements, potentially affecting patient safety and surgical outcomes. The study uses a randomized controlled design to compare peri-extubation responses between patients receiving low-dose propofol and those receiving standard care.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Emergence Agitation Rhinoplasty Patient Satisfaction

Interventions

Propofol (Sub-Anesthetic Dose)DRUG

Participants receive 0.5 mg/kg intravenous propofol as a single bolus 10 minutes before extubation.

Normal Saline (Placebo)OTHER

Participants receive an equivalent volume of normal saline 10 minutes before extubation.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Ages 18-65 years * Patients scheduled for rhinoplasty surgery * ASA physical status I-II * No respiratory tract infection * Provided written informed consent Exclusion Criteria: * Refusal to participate * Presence of any respiratory tract infection * Younger than 18 or older than 65 * ASA III-IV * Known allergy to study medications * Predicted difficult intubation

Locations (1)

Yuzuncu Yil University, Dursun Odabas Medical Center

Van, Turkey (Türkiye)

Outcomes

Primary Outcomes

Changing Preoperative Anxiety Score (STAI)

Comparison of the State-Trait Anxiety Inventory (STAI) state anxiety score measured in the preoperative waiting room (T1) with the STAI score 15 minutes after the palming technique (T2). The difference between the two time points is analyzed to assess the anxiety-reducing effect of the intervention.

Time frame: 15 minutes (T1-T2)

Secondary Outcomes

Hemodynamic Parameter Changes

Changes in heart rate (HR) values between the T1 and T2 time points. The effect of the palming technique on hemodynamic stability is evaluated.

Time frame: 15 minutes (T1-T2)

Hemodynamic Parameter Changes

Changes in mean blood pressure values between the T1 and T2 time points. The effect of the palming technique on hemodynamic stability is evaluated.

Time frame: 15 minutes (T1-T2)

Data from ClinicalTrials.gov

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