Clinical Characteristics and Molecular Mechanism of Patients With Obstructive Sleep Apnea

Capital Medical University500 enrolled

Overview

To clarify the clinical features of patients with obstructive sleep apnea; To construct a multi-omics database of patients with obstructive sleep apnea, and compare the effects of different degrees of sleep apnea on prognosis, immunity, and metabolism. The medium and long-term prognosis, complications, comorbidities, risk factors, and immune and metabolic dynamics of patients with sleep apnea after treatment were studied. To elucidate the biomarkers and therapeutic targets associated with obstructive sleep apnea.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Obstructive Sleep Apnea

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with suspected obstructive sleep apnea (OSA) admitted to the sleep center of the respiratory Department of Beijing Chaoyang Hospital, Capital Medical University. * Volunteer to participate in the study and sign an informed consent, and can complete at least 1 year of follow-up. Exclusion Criteria: * Patients with obstructive sleep apnea who have been treated with impermanent positive pressure ventilation; * Pregnant or lactating women; * Patients with severe respiratory failure requiring mechanical ventilation; * Patients with severe heart, lung, liver, kidney, and central nervous system damage; * Refuse to participate in follow-up visits and/or take biological samples.

Locations (1)

Outcomes

Primary Outcomes

Multiple-omics features

ELISA ,proteomics and metabolomics were performed on blood, saliva, urine

Time frame: Within 24 hours of admission，and samples of patients receiving treatment were also collected six months and one year after treatment