Effects of Active Upper-Limb Exoskeleton Training in Simulated Hyper-Gravity on Fine Motor Performance, Brain-Muscle Connectivity, Cardiovascular System and Stress Responses in Real Hyper-Gravity

Inclusion Criteria: * Maximum weight of 90 kg * Maximum sitting butt-to-shoulder distance of 70 cm * Certified as healthy by a comprehensive clinical assessment * Normal or corrected to normal vision * Right-handed tested with Edinburgh-Handedness-Inventory-Test (≥6th percentile, on https://www.brainmapping.org/shared/Edinburgh.php) * Non smokers * No alcohol or drug dependence, no medical treatment on a regular basis * Affiliated to a Social Security system and, for non-French resident, holding a European Health Insurance Card (EHIC) or a Global Health Insurance Card (GHIC). * Free of any engagement during the study * Test subjects must be able to understand and speak English * Who agreed to take part in the study and signed the informed consent Exclusion Criteria: * Left-handed tested with Edinburgh-Handedness-Inventory-Test (\<6th percentile) * Subjects with experience in experiments on a short arm human centrifuge or under real hyper-gravity * Non-tolerance to the centrifugation * Any history or presence of clinically relevant chronic disease * Refusal to give permission to contact his general practitioner, * Subject who, in the judgment of the investigator, is likely to be non-compliant during the study, or unable to cooperate because of a language problem or poor mental development, * Subject in the exclusion period of a clinical research, * Subject who has received more than 6000 Euros within 12 months for being a research subject, * Subject who cannot be contacted in case of emergency, * Vulnerable people according to law "Code de la Santé Publique" (L1121-5 to L1121-8)