Implications of Post-Operative Irrigation Fluid's Osmolarity on the Recurrence of Non-Muscle Invasive Bladder Cancer Following Transurethral Resection

Ain Shams University150 enrolled

Overview

This randomized controlled trial will evaluate the efficacy of three bladder irrigation solutions - distilled water (DW), normal saline (NS), and hypertonic saline (HS) - as continuous bladder irrigation (CBI) following transurethral resection of non-muscle invasive bladder cancer (NMIBC). Short term (6 months) recurrence and progression free survival are mainly evaluated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

150

Conditions

Bladder (Urothelial, Transitional Cell) Cancer Nonmuscle Invasive Bladder Cancer Irrigation Hypertonic Saline Normal Saline

Interventions

Continuous Bladder Irrigation with distilled waterDRUG

Continuous Bladder Irrigation with distilled water post non muscle invasive bladder cancer urethral resection by endoscopy

Continuous Bladder Irrigation with normal salineDRUG

Continuous Bladder Irrigation with normal saline post non muscle invasive bladder cancer urethral resection by endoscopy

Continuous Bladder Irrigation with hypertonic salineDRUG

Continuous Bladder Irrigation with hypertonic saline post non muscle invasive bladder cancer urethral resection by endoscopy

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients of non-muscle invasive urinary bladder urothelial carcinoma amenable for complete resection Exclusion Criteria: * Patients with post-operative complications that need prolonged irrigation. * Patient who underwent incomplete resection during TURBT. * When large bladder perforation was suspected during TURBT. * Patients with chronic kidney disease. * Muscle invasive disease

Outcomes

Primary Outcomes

Risk of Recurrence

Time frame: 6 months

Risk of progression of bladder cancer