The aim of the study is to monitor changes in muscle mass in critically ill patients and to verify whether a decrease in muscle mass of ≥10% during the first 7 days of hospitalization is associated with increased 28-day mortality. We will be used ultrasoud for measurement the rectus femoris cross sectional area.
All patients will be admitted to participating ICU centers from December 2025 to December 2026 will be screened and enrolled based on the inclusion and exclusion criteria. Informed consent will be requested. Ultrasound measurements will be performed by the same investigator within the first 24h after ICU admssion and again on day 7 of the patient´s ICU stay. All patient data will be entered into case report form by a study physician. In the follow-up will be determined 28 mortality.
Study Type
OBSERVATIONAL
Enrollment
386
The University Hospital Brno
Brno, Bohunice, Czechia
Relationship between muscle loss and 28 day mortality
Critically ill patients with a ≥10% decrease in rectus femoris cross-sectional area have increased 28 day mortality.
Time frame: 28 days after enrollment
Incidence of a significant decrease in rectus femoris cross-sectional area
A decrease in rectus femoris cross-sectional area of 10% or more measured by ultrasound.
Time frame: first 7 days of ICU stay
Incidence of an insignificant decrease in rectus femoris cross-sectional area
A decrease in rectus femoris cross-sectional area of less than 10% measured by ultrasound.
Time frame: first 7 days ICU stay
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