Comparing Microneedling and Injectable Platelet Rich Fibrin to Hyaluronic Acid In Papilla Reconstruction

Early Phase 1Active Not RecruitingNCT07280507

King Abdulaziz University7 enrolled

Overview

This randomized split-mouth clinical trial aims to compare the clinical effectiveness of microneedling combined with injectable platelet-rich fibrin (i-PRF) versus hyaluronic acid (HA) gel injection in the reconstruction of Class I interdental papilla loss. The study hypothesizes that MN + i-PRF will yield greater papillary regeneration, offering a minimally invasive, biologically active alternative to traditional surgical approaches for soft-tissue esthetic rehabilitation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Papilla Reconstruction

Interventions

Injectable Platelet Rich FibrinBIOLOGICAL

Injectable Platelet Rich Fibrin

Hyaluronic Acid (HA)OTHER

Filler

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Plaque index \<1 * Gingival index \<1 * Class I papillary loss (Nordland and Tarnow classification) * Probing depth ≤4 mm at the test site * Inter-proximal bone crest distance ≤7 mm from the contact point. Exclusion Criteria: * Pregnancy * Lactation * Uncontrolled systemic diseases (e.g., diabetes) * Anticoagulant therapy * Recent radiotherapy * Orthodontic treatment * Midline diastema * High frenum attachment * Class II/III papillary loss.

Locations (1)

King AbdulAziz University

Jeddah, Saudi Arabia

Outcomes

Primary Outcomes

Papillary height

from the mucogingival junction to the papilla tip

Time frame: Baseline, 6 weeks, and 12 weeks.

Papillary width

Time frame: 12 weeks

Data from ClinicalTrials.gov

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