Prospective, Randomized, Sham-controlled, Dose-finding I/II Trial of Safety and Efficacy of Modified Optogenetic Gene Therapy (ZM-02 Injection)

Inclusion Criteria 1. Male or female participants aged 6 to 60 years. 2. Clinical diagnosis of advanced retinitis pigmentosa (RP). 3. Best corrected visual acuity at or below the protocol-defined threshold in the study eye. 4. Presence of sufficient retinal structure in the study eye as determined by screening assessments. 5. Ability to understand and sign informed consent (and assent, when applicable). Exclusion Criteria 1. Presence of other ocular conditions that could interfere with study assessments. 2. History of significant ocular surgery in the study eye within a protocol-defined period. 3. Active ocular infection or inflammation. 4. Clinically significant systemic disease that could increase study risk or interfere with assessments. 5. Positive screening for clinically significant infectious diseases, as defined in the protocol. 6. Pregnant or breastfeeding individuals. 7. Any condition that, in the investigator's judgment, would make the participant unsuitable for study participation.