This is a Phase I Clinical Study to Evaluate the Safety, Efficacy, and PK/PD Characteristics of HSK47977 Tablets in Subjects with Relapsed or Refractory Non-Hodgkin's Lymphoma.This study includes a Phase Ia dose-escalation stage and a Phase Ib dose-expansion stage, and it is expected to take approximately 2 years.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
110
Taken orally once daily.
Chinese Academy of Medical Sciences Blood Diseases Hospital
Tianjin, China
RECRUITINGMaximum tolerated dose (MTD)
Highest dose level at which under 33% of patients in a cohort experience DLT(dose limiting toxicity)
Time frame: Within first 28 days of treatment
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