The purpose of this study is to collect pancreas fluid from the duodenum using the endoscopic pancreas function collection method in healthy participants after pancreatic stimulation with human secretin.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
24
During endoscopic ultrasound (EUS), a dose of intravenous secretin (0.2 µg/kg) will be administered over the course of 1 minute to stimulate pancreatic ductal cells to secrete pancreas fluid. Duodenal fluid will be aspirated through the echoendoscope in 5 minute increments (5, 10, 15, and 20 minutes) after the secretin has been administered
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Pancreatic Fluid Bicarbonate Composition
A primary outcome will be the bicarbonate level (milliequivalent per liter) in the pancreatic fluid collected.
Time frame: 5, 10, 15, and 20-minutes post-secretin administration
Pancreatic Fluid Sodium Composition
A primary outcome will be the sodium level (milliequivalent per liter) in the pancreatic fluid collected.
Time frame: 5, 10, 15, and 20-minutes post-secretin administration
Pancreatic Fluid Potassium Composition
A primary outcome will be the potassium level (milliequivalent per liter) in the pancreatic fluid collected.
Time frame: 5, 10, 15, and 20-minutes post-secretin administration
Pancreatic Fluid Chloride Composition
A primary outcome will be the chloride level (milliequivalent per liter) in the pancreatic fluid collected.
Time frame: 5, 10, 15, and 20-minutes post-secretin administration
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