Evaluation of the Variation Over Time of Visuospatial Deficit in Patients With Parietal Lobe Glioma

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta40 enrolled

Overview

The goal of modern neurooncological surgery is to obtain maximum tumor resection while preserving neurological function. Parietal lobe gliomas often cause attention deficits (hemineglect) that are difficult to differentiate from other deficits. This study aims to evaluate the extent and variation over time of visuo-spatial deficits in patients undergoing surgical removal of parietal lobe gliomas. This will help characterize the cognitive profile of these patients to identify personalized treatment and rehabilitation paths.

This is a single-centre, prospective, cross-sectional, observational study involving 40 patients with high- and low-grade parietal lobe glioma. The study investigates the prevalence of subjects who show a performance in cognitive visuo-spatial tests below the cut-off of the normative sample. It evaluates associations with patient-reported outcome measures (ADL, IADL), clinical-demographic aspects, radiological data (MRI), and histological/molecular data. Assessments occur at screening (pre-surgery), and at follow-up visits (3-4 months and 6 months post-surgery). Neuropsychological tests include Line Bisection, Bell and Letter Cancellation, Reading test, Apple Cancellation, and Fluff test.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Glioma Parietal Lobe Glioma Visuspatial Deficit Unilateral Spatial Neglect (USN)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients \>18 years old * Patients must understand the Italian Language * Patients with suspected parietal lobe glioma Exclusion Criteria: * Tumor site other than parietal lobe. * Patients who cannot undergo surgical resection (stereotactic/open biopsy). * Patients who received a previous chemotherapy and/or radiotherapy treatment. * Patients with a history of intracranial mass lesion or traumatic brain injury. * Patients with a history of other CNS diseases (e.g., stroke, metastasis). * Patients with diagnosis of neurodegenerative disease (i.e. Alzheimer's Disease, Frontotemporal Dementia, Parkinson's Disease, Lewy Body Dementia, Amyotrophic Lateral Sclerosis).

Outcomes

Primary Outcomes

Change in Visuospatial Deficit Prevalence

Prevalence of patients with a score below the cut-off in specific neuropsychological tests for visuo-spatial aspects (Line Bisection, Bell/Letter Cancellation, Apple Cancellation, Fluff Test) and the extent of change compared to baseline.

Time frame: Baseline (pre-surgery), 3-4 months post-surgery, 6 months post-surgery.

Secondary Outcomes

Association with Radiological Data

Correlation between visuo-spatial deficit scores and MRI data (FLAIR volume, T1 contrast, necrosis, localization).

Time frame: Up to 6 months post-surgery

Association with Clinical-Demographic Data

Correlation between visuo-spatial scores and hemispheric dominance, age, sex, and education.

Time frame: Up to 6 months post-surgery.

Association with Performance Status

Correlation between visuo-spatial scores and Karnofsky Performance Status (KPS).

Time frame: Time Frame: Up to 6 months post-surgery.

Association with Histological/Molecular Data

Correlation between visuo-spatial scores and tumor grade, histological and molecular features.