Application of Growth Factors Derived From Platelets to Accelerate Healing and Reduce Post-extraction Complications in Diabetic Individuals

N/AEnrolling By InvitationNCT07287475

King Abdulaziz University12 enrolled

Overview

To evaluate soft tissue closure in diabetic extraction sockets using digital scans. To compare healing between sockets treated with Advanced Platelet Rich Fibrin (A-PRF) vs. untreated control sites. To assess post-operative discomfort and patient satisfaction.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Diabete Mellitus

Interventions

Platelet rich fibrinPROCEDURE

Description: A-PRF is a biologically active scaffold that fits into the proven principles of the physiology of the wound-healing process. Its action lies in the controlled and prolonged release of fundamental factors like the PDGF (platelet-derived growth factor), TGF-β (transforming growth factor beta), and VEGF (vascular endothelial growth factor) which collectively enhance cellular migration, angiogenic events, and extracellular matrix remodeling factors of repair in the recovery of the tissues.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Eighteen years or older * Need bilateral tooth extraction * Sockets should be the same size * Diabetic/ uncontrolled * No other disease * Non- smoker * Non-pregnant or lactating female Exclusion Criteria: * Patients below 18 years * Patients with diseases different from diabetes * Bleeding disorders * Pregnancy * Lactation, * Tobacco use (conventional or electronic)

Locations (1)

King AbdulAziz University

Jeddah, Mekkah, Saudi Arabia

Outcomes

Primary Outcomes

Socket size

Soft tissue healing of extraction sockets

Time frame: 3 weeks

Data from ClinicalTrials.gov

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