In this study aimed to investigate the effect of nutrition on periodontal status in individuals diagnosed with obesity and without any other systemic disease, and to investigate the relationship between DII and periodontal disease risk. A total of 200 participants will be included in the study. Participants' overall daily Dietary Inflammatory Index (DII) scores will be calculated. The obtained scores will be divided into four groups, from low to high: Q1 (n=50), Q2 (n=50), Q3 (n=50), and Q4 (n=50). According to the DII, groups Q1 and Q2, which include lower scores, represent individuals on an anti-inflammatory diet, while groups Q3 and Q4, which include higher scores, represent individuals on a pro-inflammatory diet. Interleukin (IL)-1β, IL-10, total oxidant status (TOS), and total antioxidant status (TAS) were collected from gingival crevicular fluid (GCF) and serum samples. The levels of biomarkers such as malondialdehyde (MDA), glutathione (GSH), leptin, adiponectin, tumor necrosis factor (TNF)-α and C-reactive protein (CRP) from serum samples alone will be analyzed by ELISA method at the Recep Tayyip Erdoğan University Medical Biochemistry Laboratory.
Study Type
OBSERVATIONAL
Enrollment
200
Periodontal indices will be obtained from all participants
Serum and gingival crevicular fluid samples will be collected from all participants.
Recep Tayyip Erdoğan University
Rize, Turkey (Türkiye)
RECRUITINGPeriodontal pocket depth
The distance between the pocket base and the gingival margin will be measured. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.
Time frame: baseline
Clinical attachment loss
It will be calculated by measuring the distance between the cementoenemal border and the pocket base. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.
Time frame: baseline
interleukin (IL)-1β level
IL-1β levels will be measured with biochemical kits.
Time frame: baseline
interleukin (IL)-10 level
IL-10 levels will be measured with biochemical kits.
Time frame: baseline
total oxidant status (TOS) level
TOS levels will be measured with biochemical kits.
Time frame: baseline
total antioxidant status (TAS) level
TAS levels will be measured with biochemical kits.
Time frame: baseline
serum leptin level
Leptin levels in serum will be measured with biochemical kits.
Time frame: baseline
serum tumor necrosis factor (TNF)-α level
TNF-α levels in serum will be measured with biochemical kits.
Time frame: baseline
serum adiponectin level
Adiponectin levels in serum will be measured with biochemical kits.
Time frame: baseline
serum C-reactive protein (CRP) level
CRP levels in serum will be measured with biochemical kits.
Time frame: baseline
serum malondialdehyde (MDA) level
MDA levels in serum will be measured with biochemical kits.
Time frame: baseline
serum glutathione (GSH) level
GSH levels in serum will be measured with biochemical kits.
Time frame: baseline
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