This study will implement a four-week dietary intervention among middle-aged and older adults with pre-diabetes. Participants assigned to the intervention arm will replace their usual cooking oil with diacylglycerol (DAG) oil, while those in the control arm will consume colza oil. All other lifestyle behaviors will be maintained without modification. The trial will determine the impact of DAG oil consumption on glycemic regulation, lipid metabolism, and body composition in this high-risk population.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
40
This study will implement a four-week dietary intervention in which participants assigned to the intervention group will replace their habitual cooking oil with diacylglycerol (DAG) oil. All other lifestyle behaviors will be maintained without modification.
Participants assigned to the control group will consume colza oil as their cooking oil throughout a four-week dietary intervention. No other lifestyle habits or dietary behaviors will be altered.
Beijing Street
Guangzhou, Guangdong, China
Continuous Glucose Monitoring (CGM) Data
At baseline, and 4 weeks, investigators will using Continuous Glucose Monitoring (CGM) to monitor the glucose level of participants.
Time frame: up to 4 weeks
weight
At baseline, and 4 weeks, investigators will examine weight.
Time frame: up to 4 weeks
fasting blood glucose
At baseline, and 4 weeks, investigators will use automatic electrochemiluminescence analyzer to examine fasting blood glucose.
Time frame: At baseline and after 4 weeks of intervention
lipid metabolism
At baseline, and 4 weeks, investigators will use automatic electrochemiluminescence analyzer to examine total cholesterol, low density lipoprotein, high density lipoprotein, triglyceride.
Time frame: At baseline and after 4 weeks of intervention
HbA1c
At baseline, and 4 weeks, investigators will use automatic electrochemiluminescence analyzer to examine HbA1c.
Time frame: At baseline and after 4 weeks of intervention
intestinal bacteria
At baseline, and 4 weeks, investigators will use 16S rRNA pyrosequencing to examine intestinal bacteria.
Time frame: up to 4 weeks
TIR (time in range)
TIR refers to the time when blood glucose is controlled within a reasonable ( target ) range (3.9\~10.0 mmol/L), measured by continuous glucose monitoring at baseline and 4 weeks.
Time frame: At baseline and after 4 weeks of intervention
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sleep quality
Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), which comprises seven components (A through G), each scored on a scale of 0-3. The total score ranges from 0 to 21, with higher scores indicating poorer sleep quality.
Time frame: up to 4 weeks
blood pressure
At baseline, and 4 weeks, investigators will test the systolic blood pressure and diastolic blood pressure using automatic digital blood pressure monitor.
Time frame: up to 4 weeks