Conformity of Conjunctival Hyperemia Assessment in Soft Contact Lens Wearers Using Image J Analysis and Efron Degree System

Universitas Indonesia52 enrolled

Overview

Soft Contact Lens (SCL) use all over the world is still increasing. Ocular surface inflammatory reaction is the most common risk of using SCL. Currently, the standard used to assess this complication is the Efron Degree System (EDS), but it has high variability due its subjectivity. ImageJ gives more objective result with conjunctival vasodilation and vascular density assessment, so that complication management can be given earlier. Purpose: Evaluate the suitability of SDE with ImageJ analysis in assessing conjunctival hyperemia in SCL use within 2 weeks.

This is a paired prospective analytic study. Subjects with myopia who have not used SCL routinely before were instructed to use SCL for 14 days. Conjunctival inflammation were assessed with slit lamp examination before, at day 7, and day 14 of using SCL. Slit lamp pictures were analysed with EDS and ImageJ to be compared.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Soft Contact Lenses

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * subject with mild to moderate myopia (-0.50 to -6.00 D) * age between 18-45 years old * subject who refuse refractive correction with glasses or surgery * patient with astigmatism refractive error no more than -1 Diopter Exclusion Criteria: * subject with previous intraocular surgery * subject who is wearing SCL continuously * subject with history of dry eyes, uveitis, glaucoma, or corneal and conjunctival disorders * subject with history of allergic reaction to contact lens material or lens wetting solution used in this study * subject with ongoing eye drop treatment * female subject with ongoing pregnancy or on breastfeeding * subject with too improper lens fitting * subject who work around exposure of chemical substance, smoke, hazardous gas, or fire sparks

Outcomes

Primary Outcomes

Efron degree system for hyperemia degree

Hyperemia grade based on Efron degree system, identified by percentage of hyperemia on the bulbar dan limbal conjunctiva * Normal * Trace * Mild * Moderate * Severe

Time frame: on day 0 (before using SCL), day 7, and day 14

Image J analysis of hyperemia degree

Vascular density (%area) and Vascular diameter (μm )