Older survivors of blood cancer are at a high risk of accelerated biological aging, which increases their risk of developing multiple aging-related conditions. Whereas physical exercise can improve overall health, older cancer survivors do not meet the recommended physical activity, highlighting the need to develop behavioral interventions to increase adherence. Several other knowledge gaps exist to implement exercise interventions in older survivors of blood cancer; the dose and duration of exercise necessary to slow biological aging in older blood cancer survivors remain unknown. To bridge these gaps in knowledge, we have designed a Phase 2 randomized control trial to test the effects of behavioral and exercise interventions on various outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
180
Intervention arm incorporating virtually supervised moderate-intensity aerobic exercise and behavioral intervention/coaching to improve adherence
Access to a virtual exercise platform that provides exercise classes and educational sessions for older survivors of blood cancer
University of Nebraska Medical Center
Omaha, Nebraska, United States
RECRUITINGPercentage of participants who adhered to the exercise regimen at 6-months post enrollment.
Participants achieving at least 120 minutes per week of moderate-intensity aerobic exercise, measured using Polar heart rate monitor data and exercise diaries.
Time frame: 6 Months from start of program
Percentage of participants who adhered to the exercise regimen at 12-months post enrollment.
Participants achieving at least 120 minutes per week of moderate-intensity aerobic exercise, measured using Polar heart rate monitor data and exercise diaries to assess sustainability of adherence.
Time frame: 12 Months from start of program.
Physical Function (6- Minute Walk Test Distance)
Distance covered during the 6-minute walk test (6MWT) to assess physical function.
Time frame: 6 months from randomization
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