Before extubation during the anesthesia recovery period, 100% oxygen is routinely inhaled to increase the oxygen reserves, maximizing the time window for anesthesiologists to adjust strategies when they encounter hypoxemia after extubation. However, even inhaling a short period of pure oxygen can cause absorptive atelectasis, and may even impair the effectiveness of intraoperative protective ventilation measures continuing to post-operative period. The purpose of this study is to determine whether 30% oxygen before extubation after abdominal surgery could reduce hypoxemia incidence after extubation during the recovery period or not, compared to 100% oxygen. 590 patients scheduled to abdominal surgeries, will be randomly assigned to receive 30% or 100% oxygen concentration from the end of surgery to extubation after general anesthesia in the post-anesthesia care unit. The incidence of hypoxemia (SpO2 \< 90%) from extubation to leaving the post-anesthesia care unit (PACU) is the primary outcome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
590
Oxygen concentration inhaled from the end of surgery to tracheal extubation after general anesthesia in the recovery period is 100%.
Oxygen concentration inhaled from the end of surgery to tracheal extubation after general anesthesia in the recovery period is 30%.
the Sixth Affiliated Hospital of Sun Yat-Sen University
Guangzhou, Guangdong, China
Incidence of hypoxemia
Time frame: At the day of surgery from tracheal extubation to leaving the post-anesthesia care unit
Incidence of post operative pulmonary-related complications
Time frame: Within 7 days after surgery
Incidence of severe hypoxemia
Time frame: At the day of surgery from tracheal extubation to leaving the post-anesthesia care unit
Arterial partial pressure of oxygen (PaO2)
Time frame: At the day of surgery after tracheal extubation in the post-anesthesia care unit
Score of lung ultrasound
The score of lung ultrasound ranges from 0 to 36, and a higher score means a worse ventilation.
Time frame: At the day of surgery after tracheal extubation in the post-anesthesia care unit
Area of atelectasis shown on chest CT
Time frame: At the day of surgery after tracheal extubation
Number of patients unplanned transfers to the ICU
Time frame: 30 days after surgery
Length of postoperative stay
Time frame: At hospital discharge
Number of patients return to the hospital after discharge
Time frame: 30 days after surgery
Number of deaths
Time frame: 30 days after surgery
Number of patients with important organ disfunction after surgery, including arrhythmia, acute myocardial injury, heart failure, renal function injury, liver function injury, and cerebrovascular accident.
Time frame: 30 days after surgery
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