Prognostic Values of Coronary Microvascular Dysfunction in Patients With Dilated Cardiomyopathy

Second Affiliated Hospital, School of Medicine, Zhejiang University330 enrolled

Overview

The goal of this observational study is to learn about the long-term prognostic of coronary microvascular dysfuction in Patients with Dilated Cardiomyopathy. The main question it aims to answer is: Does the coronary microvascular dysfunction impact the outcomes in Patients with Dilated Cardiomyopathy.

Study Type

OBSERVATIONAL

Enrollment

330

Conditions

Dilated Cardiomyopathy (DCM)

Interventions

coronary angiographyPROCEDURE

Patients should undergo coronary angiography to confirm the absence of significant coronary stenosis. Angio-IMR was calculated based on the angiography.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Dilated cardiomyopathy comfirmed by echocardiography: LVDd \> 55 mm in men or \> 50 mm in women. * Clinically evident congestive heart failure: Compatible symptoms and signs, and BNP ≥ 35 pg/mL or NT-proBNP ≥ 125 pg/mL, and LV systolic dysfunction defined by LVEF \< 45 %. * Coronary angiography showing stenosis ≤ 50 % in all major epicardial vessels. Exclusion Criteria: * Patients with coronary artery disease, hypertensive heart disease, rheumatic valvular heart disease, myocarditis, and other secondary cardiomyopathies. * poor angiographic image quality

Locations (1)

The second affiliated hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

RECRUITING

Outcomes

Primary Outcomes

Major adverse cardiac events

A composite of cardiac death, hospitalization for heart failure, heart transplantation, and device implantation

Time frame: At 5-year follow-up

Central Contacts

Jun Jiang, MD

CONTACT

+86 15657125311 21918219@zju.edu.cn

Data from ClinicalTrials.gov

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