Effect of Antifungals on the Intestinal Microbiome - a Randomized, Controlled, Proof-of-concept Trial

Inclusion Criteria: * Male, 18-35 years of age at the time of signing informed consent * Healthy, as determined by medical history and physical examination; minor clinical abnormalities allowed if not introducing additional risk or interfering with study procedures * Capable of giving written informed consent and able to comply with study requirements * Normal defecation pattern (≤3 times/day and ≥3 times/week) Exclusion Criteria: * Major illness in the past 3 months, or significant chronic medical illness deemed unfavorable for enrollment * Past or current gastrointestinal disease that may influence the gut microbiota (including inflammatory bowel disease or medication-treated irritable bowel syndrome) * History of immunodeficiency * History of malignancy * Alcohol intake \>3 units/day on average * Known allergy to antifungal drugs * Use of antibiotics (except topical) within the past 3 months * Use of antifungals (except topical) within the past 3 months * Planned prolonged travel (\>4 weeks) to tropical countries during the study period * Receipt of an investigational product within 3 months prior to study day 0 * Use of prescription or non-prescription drugs, herbal or dietary supplements within 3 months (unless deemed safe by investigator) * Difficulty with blood donation or poor venous access in either arm * Donation of \>500 mL of blood in the past 3 months * Any other condition or circumstance that, in the investigator's opinion, could be harmful to the subject or compromise data interpretation