The goal of this clinical trial is to assess whether probiotic supplementation can improve the hematological response of CKD patients to erythropoietin therapy and prevent or reduce erythropoietin resistance. The main questions it aims to answer are: Can probiotic be used as an adjuvant strategy in anemia management and increasing ESA responsiveness in CKD? What medical problems do participants have when taking probiotic? Researchers will compare Erythropoietin only with Erythropoietin + Probiotic to see if Probiotic aids in treating anaemic chronic kidney disease patients. Participants will: Take Erythropoietin + Probiotic or Probiotic only every day for 3 months Visit the clinic once every 4 weeks for checkups and tests Keep a diary of their symptoms
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
80
Anaemic chronic kidney disease patients on regular hemodialysis treated with Erythropoietin + Probiotic
Anaemic chronic kidney disease patients on regular hemodialysis treated with Erythropoietin
- Hemoglobin concentration
\- Hemoglobin concentration (g/dL)at 2 weeks, and 3-months postoperatively
Time frame: at baseline, and 3-months postintervention
- Erythropoietin resistance index (ERI)
\- ERI = (ESA dose per week) / (body weight) / (hemoglobin level).
Time frame: at baseline, and 3-months postintervention
C-reactive protein
mg/dl
Time frame: at baseline, and 3-months postintervention
serum urea
mg/dl
Time frame: at baseline, and 3-months postintervention
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