Vitamin A in Cord Blood and Preterm Outcomes

N/ANot Yet RecruitingNCT07296393

The First Hospital of Jilin University155 enrolled

Overview

This single-center prospective cohort study aims to describe the distribution of umbilical-cord blood vitamin A concentrations in extremely preterm infants (\<32 weeks' gestation) and to evaluate whether low cord blood vitamin A is associated with increased risk of neonatal morbidities such as bronchopulmonary dysplasia (BPD), necrotising enterocolitis (NEC), severe intraventricular haemorrhage (IVH), retinopathy of prematurity (ROP), periventricular leukomalacia (PVL), high-grade patent ductus arteriosus (hsPDA), respiratory distress syndrome (RDS), sepsis and death before discharge.

Study Type

OBSERVATIONAL

Enrollment

155

Conditions

Extremely Premature Infant

Eligibility

Sex: ALLMax age: 28 Days

Medical Language ↔ Plain English

Inclusion Criteria: Gestational age \<32 weeks Birth at First Hospital of Jilin University Umbilical cord blood sample obtained within 24 h Parental written informed consent Exclusion Criteria: Major congenital malformation or chromosomal abnormality Refusal of consent

Outcomes

Primary Outcomes

Composite adverse neonatal outcome (any of death, moderate-severe BPD, NEC≥stage II, IVH≥grade III, ROP≥stage 3, PVL, hsPDA, culture-proven sepsis)

Time frame: From birth to 36 weeks' PMA or discharge, up to 3 months chronological age.

Central Contacts

Hui Wu

CONTACT

13134318877 wuhui@jlu.edu.cn

Data from ClinicalTrials.gov

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