This study aims to characterize key mechanisms underlying the development, maintenance, and treatment of severe irritability in a clinically heterogeneous sample of school-aged youth.
Severe irritability in youth is associated with significant functional impairment and occurs across diagnostic categories. This study aims to characterize key mechanisms underlying the development, maintenance, and treatment of severe irritability in a clinically heterogeneous sample of school-aged youth. Participants will complete (a) a comprehensive, multimodal assessment - including diagnostic interviews, multi-informant behavioral ratings, and neurophysiological tasks - to evaluate core cognitive, behavioral, and psychosocial factors, and (b) evidence-based treatment (e.g., cognitive behavioral therapy). Repeated assessments throughout the study period will be used to evaluate study outcomes.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
500
Participants will receive evidence-based treatment designed to address a wide range of emotional disorders.
Florida State University
Tallahassee, Florida, United States
RECRUITINGClinical Global Impressions - Improvement Scale
Clinician-rated assessment of overall clinical change, with scores ranging from 1 (very much improved) to 7 (very much worse).
Time frame: Post-treatment (up to 28 weeks from baseline)
Affective Reactivity Index
Youth- and caregiver-reported measure of irritability, with total scores ranging from 0 to 12; higher scores indicate greater symptom severity.
Time frame: Baseline to post-treatment (up to 28 weeks)
Behavior Assessment System for Children
Youth- and caregiver-reported measure of behavioral and emotional functioning; T-scores of 70 or higher indicate clinically significant symptoms.
Time frame: Baseline to post-treatment (up to 28 weeks)
Stop-Signal
Computerized task assessing inhibitory control in youth participants; longer stop-signal reaction times reflect slower inhibitory control.
Time frame: Baseline to post-treatment (up to 28 weeks)
Global-Local
Computerized task assessing set-shifting in youth participants; longer reaction times indicate poorer performance.
Time frame: Baseline to post-treatment (up to 28 weeks)
Letter Updating
Computerized task assessing working memory updating in youth participants; higher scores indicate better updating abilities.
Time frame: Baseline to post-treatment (up to 28 weeks)
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